Various screening and diagnosis approaches for gestational diabetes mellitus and adverse pregnancy outcomes: a secondary analysis of a randomized non-inferiority field trial

IntroductionWe evaluate which screening and diagnostic approach resulted in the greatest reduction in adverse pregnancy outcomes due to increased treatment.Research design and methodsThis study presents a secondary analysis of a randomized community non-inferiority trial conducted among pregnant wom...

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Published in:BMJ open diabetes research & care 2023-12, Vol.11 (6), p.e003510
Main Authors: Ramezani Tehrani, Fahimeh, Sheidaei, Ali, Rahmati, Maryam, Farzadfar, Farshad, Noroozzadeh, Mahsa, Hosseinpanah, Farhad, Abedini, Mehrandokht, Hadaegh, Farzad, Valizadeh, Majid, Torkestani, Farahnaz, Khalili, Davood, Firouzi, Faegheh, Solaymani-Dodaran, Masoud, Ostovar, Afshin, Azizi, Fereidoun, Behboudi-Gandevani, Samira
Format: Article
Language:English
Subjects:
Cardiovascular and Metabolic Risk
Cesarean Section
Cities
Diabetes, Gestational
Diabetes, Gestational - diagnosis
Diabetes, Gestational - epidemiology
Fasting
Female
Fetal Macrosomia - diagnosis
Fetal Macrosomia - epidemiology
Gestational diabetes
Glucose
Glucose Tolerance Test
Health care
Humans
Infant, Newborn
Medical diagnosis
Pregnancy
Pregnancy Outcome - epidemiology
Prenatal care
Weight Gain
Womens health
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Summary:IntroductionWe evaluate which screening and diagnostic approach resulted in the greatest reduction in adverse pregnancy outcomes due to increased treatment.Research design and methodsThis study presents a secondary analysis of a randomized community non-inferiority trial conducted among pregnant women participating in the GULF Study in Iran. A total of 35 430 pregnant women were randomly assigned to one of the five prespecified gestational diabetes mellitus (GDM) screening protocols. The screening methods included fasting plasma glucose (FPG) in the first trimester and either a one-step or a two-step screening method in the second trimester of pregnancy. According to the results, participants were classified into 6 groups (1) First-trimester FPG: 100–126 mg/dL, GDM diagnosed at first trimester; (2) First trimester FPG: 92–99.9 mg/dL, GDM diagnosed at first trimester; (3) First trimester FPG: 92–99.9 mg/dL, GDM diagnosed at second trimester; (4) First trimester FPG: 92–99.9 mg/dL, healthy at second trimester; (5) First trimester FPG
ISSN:2052-4897
2052-4897
DOI:10.1136/bmjdrc-2023-003510