Loading…
Sequential delivery of IL-10 and icariin using nanoparticle/hydrogel hybrid system for prompting bone defect repair
The treatment of large bone defects remains challenging due to the lack of spatiotemporal management of the immune microenvironment, inflammation response and bone remodeling. To address these issues, we designed and developed a nanoparticle/hydrogel hybrid system that can achieve the combined and s...
Saved in:
Published in: | Materials today bio 2024-12, Vol.29, p.101374, Article 101374 |
---|---|
Main Authors: | , , , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | |
---|---|
cites | |
container_end_page | |
container_issue | |
container_start_page | 101374 |
container_title | Materials today bio |
container_volume | 29 |
creator | Li, Xiaojun Sun, Zeyue Shang, Xiushuai Chen, Liuting Shi, Xiaofeng Xu, Wei Fu, Shaotian He, Qingling Liang, Qihao Ma, Jie Sun, Xin Lu, Jiaju Jin, Wenjie |
description | The treatment of large bone defects remains challenging due to the lack of spatiotemporal management of the immune microenvironment, inflammation response and bone remodeling. To address these issues, we designed and developed a nanoparticle/hydrogel hybrid system that can achieve the combined and sequential delivery of an anti-inflammatory factor (IL-10) and osteogenic drug (icariin, ICA). A photopolymerizable composite hydrogel was prepared by combining gelatin methacryloyl (GelMA) and heparin-based acrylated hyaluronic acid (HA) hydrogels containing IL-10, and poly(dl-lactide-co-glycolide) (PLGA)-HA nanoparticles loaded with ICA were incorporated into the composite hydrogels. The nanoparticle/hydrogel hybrid system demonstrates an array of features including mechanical strength, injectability and photo-crosslinking. The rapid release of IL-10 from the hydrogel effectively exerts immunomodulatory activity, whereas the long-term sustained release of icariin from the PLGA-HA nanoparticles significantly triggers the osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs). Notably, the combined delivery of IL-10 and ICA from the hybrid system exhibit a synergistic effect for bone remodeling in a critical cranial defect rat model. Our findings indicate the importance of the immunomodulatory microenvironment and osteogenic differentiation for high-quality skull remodeling, and thus the dual-factor releasing nanoparticle/hydrogel hybrid system could be a promising candidate for repairing bone defects.
[Display omitted] |
doi_str_mv | 10.1016/j.mtbio.2024.101374 |
format | article |
fullrecord | <record><control><sourceid>elsevier_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_80f54693e90d434eadfc36136f821843</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S2590006424004356</els_id><doaj_id>oai_doaj_org_article_80f54693e90d434eadfc36136f821843</doaj_id><sourcerecordid>S2590006424004356</sourcerecordid><originalsourceid>FETCH-LOGICAL-d1654-305537dc430da99497315a17c94d46b819c332cbdf222b761734b04947d1b9333</originalsourceid><addsrcrecordid>eNpNkctqwzAQRU1poaHNF3SjH3AyevihRRcl9BEIdNF2LWRpnMjYlis7Af997SSLrma4MIe5nCh6orCiQNN1tWqGwvkVAybmhGfiJlqwREIMkIrbf_t9tOz7CgBYJgWAXET9F_4esR2cronF2p0wjMSXZLuLKRDdWuKMDs615Ni7dk9a3fpOh8GZGteH0Qa_x5ocxiI4S_qxH7AhpQ-kC77phvmi8C1O6BLNQAJ22oXH6K7UdY_L63yIft5evzcf8e7zfbt52cWWpomIOSQJz6wRHKyWUsiM00TTzEhhRVrkVBrOmSlsyRgrspRmXBQgpMgsLSTn_CHaXrjW60p1wTU6jMprp86BD3t1baJyKBORSo4SrOACtS0NTylPy5zRXMys5wsLp4dPDoPqjcPWoHVhajYRnaKgZiGqUmchahaiLkL4H6XlgAI</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Sequential delivery of IL-10 and icariin using nanoparticle/hydrogel hybrid system for prompting bone defect repair</title><source>ScienceDirect®</source><source>PubMed Central</source><creator>Li, Xiaojun ; Sun, Zeyue ; Shang, Xiushuai ; Chen, Liuting ; Shi, Xiaofeng ; Xu, Wei ; Fu, Shaotian ; He, Qingling ; Liang, Qihao ; Ma, Jie ; Sun, Xin ; Lu, Jiaju ; Jin, Wenjie</creator><creatorcontrib>Li, Xiaojun ; Sun, Zeyue ; Shang, Xiushuai ; Chen, Liuting ; Shi, Xiaofeng ; Xu, Wei ; Fu, Shaotian ; He, Qingling ; Liang, Qihao ; Ma, Jie ; Sun, Xin ; Lu, Jiaju ; Jin, Wenjie</creatorcontrib><description>The treatment of large bone defects remains challenging due to the lack of spatiotemporal management of the immune microenvironment, inflammation response and bone remodeling. To address these issues, we designed and developed a nanoparticle/hydrogel hybrid system that can achieve the combined and sequential delivery of an anti-inflammatory factor (IL-10) and osteogenic drug (icariin, ICA). A photopolymerizable composite hydrogel was prepared by combining gelatin methacryloyl (GelMA) and heparin-based acrylated hyaluronic acid (HA) hydrogels containing IL-10, and poly(dl-lactide-co-glycolide) (PLGA)-HA nanoparticles loaded with ICA were incorporated into the composite hydrogels. The nanoparticle/hydrogel hybrid system demonstrates an array of features including mechanical strength, injectability and photo-crosslinking. The rapid release of IL-10 from the hydrogel effectively exerts immunomodulatory activity, whereas the long-term sustained release of icariin from the PLGA-HA nanoparticles significantly triggers the osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs). Notably, the combined delivery of IL-10 and ICA from the hybrid system exhibit a synergistic effect for bone remodeling in a critical cranial defect rat model. Our findings indicate the importance of the immunomodulatory microenvironment and osteogenic differentiation for high-quality skull remodeling, and thus the dual-factor releasing nanoparticle/hydrogel hybrid system could be a promising candidate for repairing bone defects.
[Display omitted]</description><identifier>ISSN: 2590-0064</identifier><identifier>EISSN: 2590-0064</identifier><identifier>DOI: 10.1016/j.mtbio.2024.101374</identifier><language>eng</language><publisher>Elsevier Ltd</publisher><subject>Immunomodulation ; Injectable hydrogel ; Nanoparticles ; Osteogenesis ; Sequential release</subject><ispartof>Materials today bio, 2024-12, Vol.29, p.101374, Article 101374</ispartof><rights>2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0009-0009-8482-4616</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S2590006424004356$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3549,27924,27925,45780</link.rule.ids></links><search><creatorcontrib>Li, Xiaojun</creatorcontrib><creatorcontrib>Sun, Zeyue</creatorcontrib><creatorcontrib>Shang, Xiushuai</creatorcontrib><creatorcontrib>Chen, Liuting</creatorcontrib><creatorcontrib>Shi, Xiaofeng</creatorcontrib><creatorcontrib>Xu, Wei</creatorcontrib><creatorcontrib>Fu, Shaotian</creatorcontrib><creatorcontrib>He, Qingling</creatorcontrib><creatorcontrib>Liang, Qihao</creatorcontrib><creatorcontrib>Ma, Jie</creatorcontrib><creatorcontrib>Sun, Xin</creatorcontrib><creatorcontrib>Lu, Jiaju</creatorcontrib><creatorcontrib>Jin, Wenjie</creatorcontrib><title>Sequential delivery of IL-10 and icariin using nanoparticle/hydrogel hybrid system for prompting bone defect repair</title><title>Materials today bio</title><description>The treatment of large bone defects remains challenging due to the lack of spatiotemporal management of the immune microenvironment, inflammation response and bone remodeling. To address these issues, we designed and developed a nanoparticle/hydrogel hybrid system that can achieve the combined and sequential delivery of an anti-inflammatory factor (IL-10) and osteogenic drug (icariin, ICA). A photopolymerizable composite hydrogel was prepared by combining gelatin methacryloyl (GelMA) and heparin-based acrylated hyaluronic acid (HA) hydrogels containing IL-10, and poly(dl-lactide-co-glycolide) (PLGA)-HA nanoparticles loaded with ICA were incorporated into the composite hydrogels. The nanoparticle/hydrogel hybrid system demonstrates an array of features including mechanical strength, injectability and photo-crosslinking. The rapid release of IL-10 from the hydrogel effectively exerts immunomodulatory activity, whereas the long-term sustained release of icariin from the PLGA-HA nanoparticles significantly triggers the osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs). Notably, the combined delivery of IL-10 and ICA from the hybrid system exhibit a synergistic effect for bone remodeling in a critical cranial defect rat model. Our findings indicate the importance of the immunomodulatory microenvironment and osteogenic differentiation for high-quality skull remodeling, and thus the dual-factor releasing nanoparticle/hydrogel hybrid system could be a promising candidate for repairing bone defects.
[Display omitted]</description><subject>Immunomodulation</subject><subject>Injectable hydrogel</subject><subject>Nanoparticles</subject><subject>Osteogenesis</subject><subject>Sequential release</subject><issn>2590-0064</issn><issn>2590-0064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpNkctqwzAQRU1poaHNF3SjH3AyevihRRcl9BEIdNF2LWRpnMjYlis7Af997SSLrma4MIe5nCh6orCiQNN1tWqGwvkVAybmhGfiJlqwREIMkIrbf_t9tOz7CgBYJgWAXET9F_4esR2cronF2p0wjMSXZLuLKRDdWuKMDs615Ni7dk9a3fpOh8GZGteH0Qa_x5ocxiI4S_qxH7AhpQ-kC77phvmi8C1O6BLNQAJ22oXH6K7UdY_L63yIft5evzcf8e7zfbt52cWWpomIOSQJz6wRHKyWUsiM00TTzEhhRVrkVBrOmSlsyRgrspRmXBQgpMgsLSTn_CHaXrjW60p1wTU6jMprp86BD3t1baJyKBORSo4SrOACtS0NTylPy5zRXMys5wsLp4dPDoPqjcPWoHVhajYRnaKgZiGqUmchahaiLkL4H6XlgAI</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>Li, Xiaojun</creator><creator>Sun, Zeyue</creator><creator>Shang, Xiushuai</creator><creator>Chen, Liuting</creator><creator>Shi, Xiaofeng</creator><creator>Xu, Wei</creator><creator>Fu, Shaotian</creator><creator>He, Qingling</creator><creator>Liang, Qihao</creator><creator>Ma, Jie</creator><creator>Sun, Xin</creator><creator>Lu, Jiaju</creator><creator>Jin, Wenjie</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>DOA</scope><orcidid>https://orcid.org/0009-0009-8482-4616</orcidid></search><sort><creationdate>202412</creationdate><title>Sequential delivery of IL-10 and icariin using nanoparticle/hydrogel hybrid system for prompting bone defect repair</title><author>Li, Xiaojun ; Sun, Zeyue ; Shang, Xiushuai ; Chen, Liuting ; Shi, Xiaofeng ; Xu, Wei ; Fu, Shaotian ; He, Qingling ; Liang, Qihao ; Ma, Jie ; Sun, Xin ; Lu, Jiaju ; Jin, Wenjie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-d1654-305537dc430da99497315a17c94d46b819c332cbdf222b761734b04947d1b9333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Immunomodulation</topic><topic>Injectable hydrogel</topic><topic>Nanoparticles</topic><topic>Osteogenesis</topic><topic>Sequential release</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Xiaojun</creatorcontrib><creatorcontrib>Sun, Zeyue</creatorcontrib><creatorcontrib>Shang, Xiushuai</creatorcontrib><creatorcontrib>Chen, Liuting</creatorcontrib><creatorcontrib>Shi, Xiaofeng</creatorcontrib><creatorcontrib>Xu, Wei</creatorcontrib><creatorcontrib>Fu, Shaotian</creatorcontrib><creatorcontrib>He, Qingling</creatorcontrib><creatorcontrib>Liang, Qihao</creatorcontrib><creatorcontrib>Ma, Jie</creatorcontrib><creatorcontrib>Sun, Xin</creatorcontrib><creatorcontrib>Lu, Jiaju</creatorcontrib><creatorcontrib>Jin, Wenjie</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Directory of Open Access Journals</collection><jtitle>Materials today bio</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Xiaojun</au><au>Sun, Zeyue</au><au>Shang, Xiushuai</au><au>Chen, Liuting</au><au>Shi, Xiaofeng</au><au>Xu, Wei</au><au>Fu, Shaotian</au><au>He, Qingling</au><au>Liang, Qihao</au><au>Ma, Jie</au><au>Sun, Xin</au><au>Lu, Jiaju</au><au>Jin, Wenjie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sequential delivery of IL-10 and icariin using nanoparticle/hydrogel hybrid system for prompting bone defect repair</atitle><jtitle>Materials today bio</jtitle><date>2024-12</date><risdate>2024</risdate><volume>29</volume><spage>101374</spage><pages>101374-</pages><artnum>101374</artnum><issn>2590-0064</issn><eissn>2590-0064</eissn><abstract>The treatment of large bone defects remains challenging due to the lack of spatiotemporal management of the immune microenvironment, inflammation response and bone remodeling. To address these issues, we designed and developed a nanoparticle/hydrogel hybrid system that can achieve the combined and sequential delivery of an anti-inflammatory factor (IL-10) and osteogenic drug (icariin, ICA). A photopolymerizable composite hydrogel was prepared by combining gelatin methacryloyl (GelMA) and heparin-based acrylated hyaluronic acid (HA) hydrogels containing IL-10, and poly(dl-lactide-co-glycolide) (PLGA)-HA nanoparticles loaded with ICA were incorporated into the composite hydrogels. The nanoparticle/hydrogel hybrid system demonstrates an array of features including mechanical strength, injectability and photo-crosslinking. The rapid release of IL-10 from the hydrogel effectively exerts immunomodulatory activity, whereas the long-term sustained release of icariin from the PLGA-HA nanoparticles significantly triggers the osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs). Notably, the combined delivery of IL-10 and ICA from the hybrid system exhibit a synergistic effect for bone remodeling in a critical cranial defect rat model. Our findings indicate the importance of the immunomodulatory microenvironment and osteogenic differentiation for high-quality skull remodeling, and thus the dual-factor releasing nanoparticle/hydrogel hybrid system could be a promising candidate for repairing bone defects.
[Display omitted]</abstract><pub>Elsevier Ltd</pub><doi>10.1016/j.mtbio.2024.101374</doi><orcidid>https://orcid.org/0009-0009-8482-4616</orcidid><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 2590-0064 |
ispartof | Materials today bio, 2024-12, Vol.29, p.101374, Article 101374 |
issn | 2590-0064 2590-0064 |
language | eng |
recordid | cdi_doaj_primary_oai_doaj_org_article_80f54693e90d434eadfc36136f821843 |
source | ScienceDirect®; PubMed Central |
subjects | Immunomodulation Injectable hydrogel Nanoparticles Osteogenesis Sequential release |
title | Sequential delivery of IL-10 and icariin using nanoparticle/hydrogel hybrid system for prompting bone defect repair |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T08%3A35%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-elsevier_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sequential%20delivery%20of%20IL-10%20and%20icariin%20using%20nanoparticle/hydrogel%20hybrid%20system%20for%20prompting%20bone%20defect%20repair&rft.jtitle=Materials%20today%20bio&rft.au=Li,%20Xiaojun&rft.date=2024-12&rft.volume=29&rft.spage=101374&rft.pages=101374-&rft.artnum=101374&rft.issn=2590-0064&rft.eissn=2590-0064&rft_id=info:doi/10.1016/j.mtbio.2024.101374&rft_dat=%3Celsevier_doaj_%3ES2590006424004356%3C/elsevier_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-d1654-305537dc430da99497315a17c94d46b819c332cbdf222b761734b04947d1b9333%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |