Iron-Catalyzed Acceptorless Dehydrogenative Coupling of Alcohols With Aromatic Diamines: Selective Synthesis of 1,2-Disubstituted Benzimidazoles

Benzimidazoles are important -heteroaromatic compounds with various biological activities and pharmacological applications. Herein, we present the first iron-catalyzed selective synthesis of 1,2-disubstituted benzimidazoles acceptorless dehydrogenative coupling of primary alcohols with aromatic diam...

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Bibliographic Details
Published in:Frontiers in chemistry 2020-06, Vol.8, p.429-429
Main Authors: Putta, Ramachandra Reddy, Chun, Simin, Lee, Seok Beom, Oh, Dong-Chan, Hong, Suckchang
Format: Article
Language:English
Subjects:
alcohol
benzimidazoles
borrowing hydrogen
Chemistry
dehydrogenative coupling
iron catalysis
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Summary:Benzimidazoles are important -heteroaromatic compounds with various biological activities and pharmacological applications. Herein, we present the first iron-catalyzed selective synthesis of 1,2-disubstituted benzimidazoles acceptorless dehydrogenative coupling of primary alcohols with aromatic diamines. The tricarbonyl (η -cyclopentadienone) iron complex catalyzed dehydrogenative cyclization, releasing water and hydrogen gas as by-products. The earth abundance and low toxicity of iron metal enable the provision of an eco-friendly and efficient catalytic method for the synthesis of benzimidazoles.
ISSN:2296-2646
2296-2646
DOI:10.3389/fchem.2020.00429