Importation trends in antibiotics for veterinary use in Rwanda: A retrospective study between 2019 and 2021

• Published in: PloS one 2024-03, Vol.19 (3), p.e0299917-e0299917
• Main Authors: Manishimwe, Rosine, Ndayisenga, Balthazar, Habimana, Richard, Mwikarago, Ivan Emile, Habiyaremye, Theobald, Ndindibije, Jean Paul, Shyaka, Anselme, Kabatende, Joseph, Habyalimana, Vedaste, Karangwa, Charles, Bienvenu, Emile
• Format: Article
• Language: English
• Subjects: Animals; Anti-Bacterial Agents - therapeutic use; Anti-Infective Agents; Antibiotics; Bacteria; Bacterial infections; Biology and Life Sciences; Care and treatment; Complications and side effects; Dosage and administration; Drug resistance in microorganisms; Drug Resistance, Microbial; Humans; International trade; Medicine and Health Sciences; Methods; People and Places; Prevention; Retrospective Studies; Rwanda; Sulfonamides; Tetracycline; Tetracyclines; Veterinary medicine
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0299917

Estimating antibiotic consumption in animals is fundamental to guiding decision-making and research on controlling the emergence and spread of antibiotic-resistant bacteria in humans, animals, and the environment. This study aimed to establish importation trends of antibiotics for veterinary use in Rwanda between 2019 and 2021. Data was collected from the Rwanda Food and Drugs Authority's database. Quantities of imported antibiotic active ingredients were computed using the information extracted from the issued import licenses. These quantities were subsequently adjusted per animal biomass. In total, 35,291.4 kg of antibiotics were imported into Rwanda between 2019 and 2021, with an annual mean of 11,763.8 ± 1,486.9 kg. The adjustment of imported quantities of antibiotics per animal biomass revealed that 29.1 mg/kg, 24.3 mg/kg, and 30.3 mg/kg were imported in 2019, 2020, and 2021 respectively. A slight but not statistically significant decline in antibiotic importation was noted in 2020 (p-value = 0.547). Most of the imported antibiotics were indicated to be used in food-producing animals (35,253.8 kg or 99.9% of the imported antibiotics). Tetracyclines (17,768.6 kg or 50.3%), followed by sulfonamides (7,865.0 kg or 22.3%) and aminoglycosides (4,071.1 kg or 11.5%), were the most imported antibiotics over the studied period. It was noted that 78.9% of the imported antibiotics were categorized as highly important antimicrobials for human medicine. This study established a generalized overview of the importation of antibiotics for veterinary use in Rwanda. These results can serve as guidance for the control of antibiotic misuse. They can be used to make a correlation between antibiotic importation, antibiotic consumption, and the occurrence of antibiotic resistance in the country.