Novel lipid biomarkers and associated gene polymorphism in young ST-segment elevation myocardial infarction

There is an increasing prevalence of coronary artery disease (CAD) in younger individuals. Lipid biomarkers such as lipoprotein-a (Lp-a), Apo A1, Apo B and Paraoxonase-1 (PON1) serve as important risk predictors for development of CAD. There is little evidence regarding the role of lipid biomarkers...

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Published in:Indian heart journal 2023-01, Vol.75 (1), p.68-72
Main Authors: Muheeb, Ghazi, Gupta, Mohit Dayal, Kunal, Shekhar, Basia, Deepak, MP, Girish, Bansal, Ankit, Yusuf, Jamal, Mukhopadhyay, Saibal, Tyagi, Sanjay, Singh, Ritu
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Biomarkers
Coronary artery disease
Lipid
Prevention
Research Brief
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creator Muheeb, Ghazi
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description There is an increasing prevalence of coronary artery disease (CAD) in younger individuals. Lipid biomarkers such as lipoprotein-a (Lp-a), Apo A1, Apo B and Paraoxonase-1 (PON1) serve as important risk predictors for development of CAD. There is little evidence regarding the role of lipid biomarkers and their genetic polymorphisms in young (
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Lipid biomarkers such as lipoprotein-a (Lp-a), Apo A1, Apo B and Paraoxonase-1 (PON1) serve as important risk predictors for development of CAD. There is little evidence regarding the role of lipid biomarkers and their genetic polymorphisms in young (<50 years) ST-segment elevation myocardial infarction (STEMI) patients. This study included 110 young (18–50 years) STEMI patients and 110 healthy controls. Serum levels of Apo A1, Apo B, Paraoxonase-1 (PON-1) and Lipoprotein-associated phospholipase A2 (Lp-PLA2) were estimated for both patients as well as controls. Additionally, genetic polymorphisms in the Apo A1 (75G/A) and the PON1 (Q192R) genes were evaluated. Serum levels of apo B (101.31 ± 27.58 vs 75.31 ± 18.77 mg/dl; p < 0.0001), Lp(a) [87.56 ± 74.28 vs 25.81 ± 24.66 mg/dl, p < 0.0001] and Lp-PLA2 [5.97 ± 1.39 vs 3.49 ± 1.27 ng/mL, p < 0.0001] were significantly higher in patients as compared to controls. Serum levels of Apo A1 [44.76 ± 35.65 vs 95.97 ± 29.89; p < 0.0001] and PON1 [2.63 ± 1.5 vs 3.87 ± 1.47 ng/mL, p < 0.0001] were significantly lower in cases as compared with controls. Additionally, patients with genetic polymorphisms in the Apo A1 (75G/A) and the PON1 (Q192R) gene had an increased risk of STEMI. Lipid biomarkers such as Apo A1, Apo B and PON1 and their genetic polymorphism are associated with the susceptibility for STEMI in young individuals.]]></description><identifier>ISSN: 0019-4832</identifier><identifier>EISSN: 2213-3763</identifier><identifier>DOI: 10.1016/j.ihj.2022.11.014</identifier><identifier>PMID: 36574567</identifier><language>eng</language><publisher>Elsevier, a division of RELX India, Pvt. Ltd</publisher><subject>Biomarkers ; Coronary artery disease ; Lipid ; Prevention ; Research Brief</subject><ispartof>Indian heart journal, 2023-01, Vol.75 (1), p.68-72</ispartof><rights>2022</rights><rights>2022 Published by Elsevier, a division of RELX India, Pvt. 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Lipid biomarkers such as lipoprotein-a (Lp-a), Apo A1, Apo B and Paraoxonase-1 (PON1) serve as important risk predictors for development of CAD. There is little evidence regarding the role of lipid biomarkers and their genetic polymorphisms in young (<50 years) ST-segment elevation myocardial infarction (STEMI) patients. This study included 110 young (18–50 years) STEMI patients and 110 healthy controls. Serum levels of Apo A1, Apo B, Paraoxonase-1 (PON-1) and Lipoprotein-associated phospholipase A2 (Lp-PLA2) were estimated for both patients as well as controls. Additionally, genetic polymorphisms in the Apo A1 (75G/A) and the PON1 (Q192R) genes were evaluated. Serum levels of apo B (101.31 ± 27.58 vs 75.31 ± 18.77 mg/dl; p < 0.0001), Lp(a) [87.56 ± 74.28 vs 25.81 ± 24.66 mg/dl, p < 0.0001] and Lp-PLA2 [5.97 ± 1.39 vs 3.49 ± 1.27 ng/mL, p < 0.0001] were significantly higher in patients as compared to controls. Serum levels of Apo A1 [44.76 ± 35.65 vs 95.97 ± 29.89; p < 0.0001] and PON1 [2.63 ± 1.5 vs 3.87 ± 1.47 ng/mL, p < 0.0001] were significantly lower in cases as compared with controls. Additionally, patients with genetic polymorphisms in the Apo A1 (75G/A) and the PON1 (Q192R) gene had an increased risk of STEMI. Lipid biomarkers such as Apo A1, Apo B and PON1 and their genetic polymorphism are associated with the susceptibility for STEMI in young individuals.]]></description><subject>Biomarkers</subject><subject>Coronary artery disease</subject><subject>Lipid</subject><subject>Prevention</subject><subject>Research Brief</subject><issn>0019-4832</issn><issn>2213-3763</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNp9kV-L1DAUxYso7rj6AXzLF2jNzZ8mRRBkcXVh0QfX55Amt51022ZIugPz7c04IuyLTxfOvecH556qeg-0AQrth6kJ-6lhlLEGoKEgXlQ7xoDXXLX8ZbWjFLpaaM6uqjc5T5QyKTr6urrirVRCtmpXPX6PR5zJHA7Bkz7ExaZHTJnY1RObc3TBbujJiCuSQ5xPS0yHfcgLCSs5xad1JD8f6ozjgutGcMaj3UJcyXKKziYf7FwOB5vcWX1bvRrsnPHd33ld_br98nDzrb7_8fXu5vN97SSore7RKeaBCWRUUSlsryTvBYpBQKeZ7jrhdQdKa2RSOaE7xqjvKaLGnvYDv67uLlwf7WQOKZRQJxNtMH-EmEZj0xbcjEYD55YrPlgGwlOnZWul9M5raJmXsrA-XViHp35B70rMZOdn0OebNezNGI-m63SrOBQAXAAuxZwTDv-8QM25RTOZ0qI5t2gATGmxeD5ePFi-dAyYTHYBV4c-JHRbiRH-4_4NEvel4w</recordid><startdate>20230101</startdate><enddate>20230101</enddate><creator>Muheeb, Ghazi</creator><creator>Gupta, Mohit Dayal</creator><creator>Kunal, Shekhar</creator><creator>Basia, Deepak</creator><creator>MP, Girish</creator><creator>Bansal, Ankit</creator><creator>Yusuf, Jamal</creator><creator>Mukhopadhyay, Saibal</creator><creator>Tyagi, Sanjay</creator><creator>Singh, Ritu</creator><general>Elsevier, a division of RELX India, Pvt. 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Lipid biomarkers such as lipoprotein-a (Lp-a), Apo A1, Apo B and Paraoxonase-1 (PON1) serve as important risk predictors for development of CAD. There is little evidence regarding the role of lipid biomarkers and their genetic polymorphisms in young (<50 years) ST-segment elevation myocardial infarction (STEMI) patients. This study included 110 young (18–50 years) STEMI patients and 110 healthy controls. Serum levels of Apo A1, Apo B, Paraoxonase-1 (PON-1) and Lipoprotein-associated phospholipase A2 (Lp-PLA2) were estimated for both patients as well as controls. Additionally, genetic polymorphisms in the Apo A1 (75G/A) and the PON1 (Q192R) genes were evaluated. Serum levels of apo B (101.31 ± 27.58 vs 75.31 ± 18.77 mg/dl; p < 0.0001), Lp(a) [87.56 ± 74.28 vs 25.81 ± 24.66 mg/dl, p < 0.0001] and Lp-PLA2 [5.97 ± 1.39 vs 3.49 ± 1.27 ng/mL, p < 0.0001] were significantly higher in patients as compared to controls. Serum levels of Apo A1 [44.76 ± 35.65 vs 95.97 ± 29.89; p < 0.0001] and PON1 [2.63 ± 1.5 vs 3.87 ± 1.47 ng/mL, p < 0.0001] were significantly lower in cases as compared with controls. Additionally, patients with genetic polymorphisms in the Apo A1 (75G/A) and the PON1 (Q192R) gene had an increased risk of STEMI. Lipid biomarkers such as Apo A1, Apo B and PON1 and their genetic polymorphism are associated with the susceptibility for STEMI in young individuals.]]></abstract><pub>Elsevier, a division of RELX India, Pvt. Ltd</pub><pmid>36574567</pmid><doi>10.1016/j.ihj.2022.11.014</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-2857-0975</orcidid><oa>free_for_read</oa></addata></record>
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subjects Biomarkers
Coronary artery disease
Lipid
Prevention
Research Brief
title Novel lipid biomarkers and associated gene polymorphism in young ST-segment elevation myocardial infarction
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