Exercise Training-Induced MicroRNA Alterations with Protective Effects in Cardiovascular Diseases

Exercise training (ET) is an important non-drug adjuvant therapy against many human diseases, including cardiovascular diseases. The appropriate ET intensity induces beneficial adaptions and improves physiological function and cardiopulmonary fitness. The mechanisms of exercise-induced cardioprotect...

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Bibliographic Details
Published in:Reviews in cardiovascular medicine 2023-09, Vol.24 (9), p.251
Main Authors: Gao, Juan, Song, Jiaxin, Yan, Yuwei, Gokulnath, Priyanka, Vulugundam, Gururaja, Li, Guoping, Zhan, Qingyi, Jiang, Fei, Lin, Yanjuan, Xiao, Junjie
Format: Article
Language:English
Subjects:
beneficial adaption
cardiovascular diseases
exercise training
microrna
Review
therapeutic targets
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Summary:Exercise training (ET) is an important non-drug adjuvant therapy against many human diseases, including cardiovascular diseases. The appropriate ET intensity induces beneficial adaptions and improves physiological function and cardiopulmonary fitness. The mechanisms of exercise-induced cardioprotective effects are still not fully understood. However, mounting evidence suggest that microRNAs (miRNAs) play crucial role in this process and are essential in responding to exercise-stress and mediating exercise-protective effects. Thus, this review summarizes the biogenesis of miRNAs, the mechanism of miRNA action, and specifically the miRNAs involved in exercise-induced cardio-protection used as therapeutic targets for treating cardiovascular diseases.
ISSN:1530-6550
2153-8174
1530-6550
DOI:10.31083/j.rcm2409251