Importance of the origin of mesenchymal (stem) stromal cells in cancer biology: “alliance” or “war” in intercellular signals

Mesenchymal stem cells (MSCs) play a central role in the intercellular signaling within the tumor microenvironment (TME), exchanging signals with cancer cells and tumor stromal cells, such as cancer-associated fibroblasts and inflammatory mononuclear cells. Research attributes both pro-tumor and ant...

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Bibliographic Details
Published in:Cell & bioscience 2021-06, Vol.11 (1), p.1-109, Article 109
Main Authors: Eiro, Noemi, Fraile, Maria, Fernández-Francos, Silvia, Sánchez, Rosario, Costa, Luis A, Vizoso, Francisco J
Format: Article
Language:English
Subjects:
Adipocytes
Angiogenesis
Antimitotic agents
Antineoplastic agents
Apoptosis
B cells
Cancer
Cancer associated fibroblasts
Cancer therapies
Cell therapy
Clinical trials
Cytokines
Diabetes
Extracellular vesicles
Fibroblasts
Gene expression
Growth factors
Hormones
Inflammation
Leukocytes (mononuclear)
Macrophage associated cancer
Mesenchyme
Metabolism
Metastasis
Neutrophils
Placenta
Review
Secretome
Skin cancer
Stem cells
Stromal cells
Transplantation
Tropism
Tumor microenvironment
Tumors
Umbilical cord
Uterine mesenchymal stem cell
Uterus
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Summary:Mesenchymal stem cells (MSCs) play a central role in the intercellular signaling within the tumor microenvironment (TME), exchanging signals with cancer cells and tumor stromal cells, such as cancer-associated fibroblasts and inflammatory mononuclear cells. Research attributes both pro-tumor and anti-tumor actions to MSCs; however, evidence indicates that MSCs specific effect on the tumor depends on the source of the MSCs and the type of tumor. There are consistent data proving that MSCs from reproductive tissues, such as the uterus, umbilical cord or placenta, have potent anti-tumor effects and tropism towards tumor tissues. More interestingly, products derived from MSCs, such as secretome or extracellular vesicles, seem to reproduce the effects of their parental cells, showing a potential advantage for clinical treatments by avoiding the drawbacks associated with cell therapy. Given these perspectives, it appears necessary new research to optimize the production, safety and antitumor potency of the products derived from the MSCs suitable for oncological therapies.
ISSN:2045-3701
2045-3701
DOI:10.1186/s13578-021-00620-6