Recent Understandings of Biology, Prophylaxis and Treatment Strategies for Hypertrophic Scars and Keloids

Hypertrophic scars and keloids are fibroproliferative disorders that may arise after any deep cutaneous injury caused by trauma, burns, surgery, etc. Hypertrophic scars and keloids are cosmetically problematic, and in combination with functional problems such as contractures and subjective symptoms...

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Bibliographic Details
Published in:International journal of molecular sciences 2018-03, Vol.19 (3), p.711
Main Authors: Lee, Ho Jun, Jang, Yong Ju
Format: Article
Language:English
Subjects:
Angiogenesis
Biology
Blood platelets
Burns
Collagen
Cytokines
Disease prevention
Epidermal growth factor
Eutrophication
Fibroblasts
hypertrophic scar
Injuries
Insulin-like growth factors
keloid
Neutrophils
Otolaryngology
Prophylaxis
Proteins
Pruritus
Quality of life
Review
scar biology
scar prevention
scar treatment
Scars
Skin
Trauma
Tumor necrosis factor-TNF
Vascular endothelial growth factor
Wound healing
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Summary:Hypertrophic scars and keloids are fibroproliferative disorders that may arise after any deep cutaneous injury caused by trauma, burns, surgery, etc. Hypertrophic scars and keloids are cosmetically problematic, and in combination with functional problems such as contractures and subjective symptoms including pruritus, these significantly affect patients' quality of life. There have been many studies on hypertrophic scars and keloids; but the mechanisms underlying scar formation have not yet been well established, and prophylactic and treatment strategies remain unsatisfactory. In this review, the authors introduce and summarize classical concepts surrounding wound healing and review recent understandings of the biology, prevention and treatment strategies for hypertrophic scars and keloids.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms19030711