Propranolol in Use for Treatment of Complex Infant Hemangiomas: Literature Review Regarding Current Guidelines for Preassessment and Standards of Care before Initiation of Therapy

In 2008, the positive effects of propranolol on infantile hemangiomas (IH) have been discovered serendipitously by Léauté-Labrèze and her coworkers. Since then, propranolol has been in use in allday clinical practice worldwide for treatment of IH. It even caused some kind of paradigm shift in the ov...

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Bibliographic Details
Published in:TheScientificWorld 2013-01, Vol.2013 (2013), p.1-9
Main Author: Fette, Andreas
Format: Article
Language:English
Subjects:
Angiogenesis
Angiogenesis Inhibitors - adverse effects
Angiogenesis Inhibitors - therapeutic use
Antineoplastic Agents - adverse effects
Antineoplastic Agents - therapeutic use
Apoptosis
Cardiac arrhythmia
Cardiovascular disease
Child
Clinical medicine
Clinical trials
Diseases
Dosage and administration
Drug dosages
Drug therapy
Evidence-Based Medicine
Guideline Adherence - utilization
Hemangioma - diagnosis
Hemangioma - drug therapy
Hemangioma - epidemiology
Humans
Infants (Newborn)
Literature reviews
Medical Oncology - standards
Pediatrics - standards
Practice Guidelines as Topic
Propranolol - adverse effects
Propranolol - therapeutic use
Propranolol hydrochloride
Review
Standard of care
Treatment Outcome
Tumors
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Summary:In 2008, the positive effects of propranolol on infantile hemangiomas (IH) have been discovered serendipitously by Léauté-Labrèze and her coworkers. Since then, propranolol has been in use in allday clinical practice worldwide for treatment of IH. It even caused some kind of paradigm shift in the overall management of these lesions, though propranolol is still not FDA approved, respectively, in “off-label” use for this indication in the majority of institutions. Thus, the aim of this communication is to evaluate the literature for current evidence regarding guidelines for preassessment and standards of care before initiation of therapy.
ISSN:2356-6140
1537-744X
1537-744X
DOI:10.1155/2013/850193