Why Turner patients with 45, X monosomy should not be excluded from fertility preservation services

In this case report, we highlight the practical dilemma, i.e. to perform ovarian tissue cryopreservation surgery in a 45, X Turner Syndrome patient or not, by reporting on the presence of follicles in a 13-year-old female diagnosed with 45, X monosomy and an unmeasurable anti-müllerian hormone serum...

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Bibliographic Details
Published in:Reproductive biology and endocrinology 2022-09, Vol.20 (1), p.1-143, Article 143
Main Authors: Schleedoorn, MJ, Fleischer, K, Braat, DDM, Oerlemans, AJM, van der Velden, AAEM, Peek, R
Format: Article
Language:English
Subjects:
Age
Care and treatment
Chromosome mapping
Counseling
Cryopreservation
Cryopreservation of organs, tissues, etc
Daily practice challenges
Diagnosis
Fertility
Fertility counselling
Fertility presentation
Follicles
Genetic aspects
Girls
Infertility
Laparoscopy
Methods
Monosomy
Oophorectomy
Ovarian tissue cryopreservation
Ovaries
Patient outcomes
Patients
Sex chromosomes
Turner syndrome
Turner's syndrome
Ultrasonic imaging
Uterus
Vagina
X chromosomes
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Summary:In this case report, we highlight the practical dilemma, i.e. to perform ovarian tissue cryopreservation surgery in a 45, X Turner Syndrome patient or not, by reporting on the presence of follicles in a 13-year-old female diagnosed with 45, X monosomy and an unmeasurable anti-müllerian hormone serum level. We compare our results with previous research, highlight the challenges we faced in this case and provide recommendations for daily practice. Hereby, we demonstrate that excluding certain subgroups of Turner Syndrome patients (e.g. monosomy patients, and/or girls with an anti-müllerian hormone level below 2.0 ng/l) may be premature, especially based on the current state of published research data. This practical example of a challenging dilemma in the counselling of Turner Syndrome patients for fertility preservation is of interest for clinicians involved in fertility counselling and Turner Syndrome care.
ISSN:1477-7827
1477-7827
DOI:10.1186/s12958-022-01015-z