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Vitamin D Deficiency in Testicular Cancer Survivors: A Systematic Review

Testicular cancer (TC) is the most frequent tumor in young males. In the vast majority of cases, it is a curable disease; therefore, very often patients experience a long survival, also due to their young age at diagnosis. In the last decades, the role of the vitamin D deficiency related to orchiect...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-05, Vol.22 (10), p.5145
Main Authors: Schepisi, Giuseppe, Gianni, Caterina, Bleve, Sara, De Padova, Silvia, Menna, Cecilia, Lolli, Cristian, Filograna, Alessia, Conteduca, Vincenza, Urbini, Milena, GallĂ , Valentina, Casadei, Chiara, Rosti, Giovanni, De Giorgi, Ugo
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Language:English
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Summary:Testicular cancer (TC) is the most frequent tumor in young males. In the vast majority of cases, it is a curable disease; therefore, very often patients experience a long survival, also due to their young age at diagnosis. In the last decades, the role of the vitamin D deficiency related to orchiectomy has become an increasingly debated topic. Indeed, vitamin D is essential in bone metabolism and many other metabolic pathways, so its deficiency could lead to various metabolic disorders especially in long-term TC survivors. In our article, we report data from studies that evaluated the incidence of hypovitaminosis D in TC survivors compared with cohorts of healthy peers and we discuss molecular mechanisms and clinical implications.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22105145