Estrogens of multiple classes and their role in mental health disease mechanisms

Gender and sex hormones can influence a variety of mental health states, including mood, cognitive development and function, and vulnerability to neurodegenerative diseases and brain damage. Functions of neuronal cells may be altered by estrogens depending upon the availability of different physiolo...

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Bibliographic Details
Published in:International journal of women's health 2010-01, Vol.2 (default), p.153-166
Main Authors: Watson, Cheryl S, Alyea, Rebecca A, Cunningham, Kathryn A, Jeng, Yow-Jiun
Format: Article
Language:English
Subjects:
Brain
Brain damage
Disease susceptibility
Estrogens
Hormones
Isoflavones
Ligands
Mental health
Nervous system diseases
Neurodegenerative diseases
Neurons
Phenols (Class of compounds)
Physiological aspects
Physiology
Review
Sex hormones
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Summary:Gender and sex hormones can influence a variety of mental health states, including mood, cognitive development and function, and vulnerability to neurodegenerative diseases and brain damage. Functions of neuronal cells may be altered by estrogens depending upon the availability of different physiological estrogenic ligands; these ligands and their effects vary with life stages, the genetic or postgenetic regulation of receptor levels in specific tissues, or the intercession of competing nonphysiological ligands (either intentional or unintentional, beneficial to health or not). Here we review evidence for how different estrogens (physiological and environmental/dietary), acting via different estrogen receptor subtypes residing in alternative subcellular locations, influence brain functions and behavior. We also discuss the families of receptors and transporters for monoamine neurotransmitters and how they may interact with the estrogenic signaling pathways.
ISSN:1179-1411
1179-1411
DOI:10.2147/ijwh.s6907