m6A binding protein YTHDF2 in cancer

YT521-B homology domain family member 2 (YTHDF2) is an N.sup.6-methyladenosine (m.sup.6A)-binding protein that was originally found to regulate the stability of mRNA. Growing evidence has shown that YTHDF2 can participate in multifarious bioprocesses, including embryonic development, immune response...

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Bibliographic Details
Published in:Experimental hematology & oncology 2022-04, Vol.11 (1), p.1-21, Article 21
Main Authors: Chen, Xiaomin, Zhou, Xiangxiang, Wang, Xin
Format: Article
Language:English
Subjects:
Binding sites
Cancer
Cell growth
Development and progression
Embryonic development
Gastric cancer
Gene expression
Immune response
Liver cancer
m6A
Mechanism
Medical prognosis
Metastasis
Methyltransferases
Pancreatic cancer
Prognosis
Protein binding
Proteins
Review
RNA
Stem cells
Tumorigenesis
Tumors
YTHDF2
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Summary:YT521-B homology domain family member 2 (YTHDF2) is an N.sup.6-methyladenosine (m.sup.6A)-binding protein that was originally found to regulate the stability of mRNA. Growing evidence has shown that YTHDF2 can participate in multifarious bioprocesses, including embryonic development, immune response, and tumor progression. Furthermore, YTHDF2 is closely associated with the proliferation, apoptosis, invasion, and migration of tumor cells, suggesting its significant role in cancers. YTHDF2 primarily relies on m.sup.6A modification to modulate signaling pathways in cancer cells. However, the expression and function of YTHDF2 in human malignancies remain controversial. Meanwhile, the underlying molecular mechanisms of YTHDF2 have not been elucidated. In this review, we principally summarized the biological functions and molecular mechanisms of YTHDF2 in tumors and discussed its prognostic and therapeutic values. Keywords: YTHDF2, m.sup.6A, Cancer, Mechanism, Prognosis
ISSN:2162-3619
2162-3619
DOI:10.1186/s40164-022-00269-y