Nox4 Expression Is Not Required for OVX‐Induced Osteoblast Senescence and Bone Loss in Mice

ABSTRACT Estrogen deficiency and aging play critical roles in the pathophysiology of bone as a result of increased oxidative stress. It has been suggested that prevention of NADPH oxidase‐ (Nox‐) dependent accumulation of ROS may be an approach to potentially minimize bone loss caused by these condi...

Full description

Saved in:
Bibliographic Details
Published in:JBMR plus 2020-08, Vol.4 (8), p.e10376-n/a
Main Authors: Chen, Jin‐Ran, Lazarenko, Oxana P, Zhao, Haijun, Wankhade, Umesh D, Pedersen, Kim, Watt, James, Ronis, Martin J J
Format: Article
Language:English
Subjects:
Aging
Animal models
Apoptosis
Bone loss
Bone marrow
Bone mass
Estrogens
Gene deletion
Laboratory animals
NAD(P)H oxidase
NOX4
NOX4 gene
NOX4 protein
Oophorectomy
Original
OSTEOBLAST
Osteoblasts
Ovariectomy
Ovaries
Oxidative stress
p53 Protein
Phosphatase
SENESCENCE
SEX STEROID DEFICIENCY
Vertebrae
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ABSTRACT Estrogen deficiency and aging play critical roles in the pathophysiology of bone as a result of increased oxidative stress. It has been suggested that prevention of NADPH oxidase‐ (Nox‐) dependent accumulation of ROS may be an approach to potentially minimize bone loss caused by these conditions. Using ovariectomized (OVX) and Nox4 gene‐deletion mouse models, we investigated the role of Nox4 in OVX‐induced bone loss and osteoblast senescence signaling. Six‐month‐old WT C57Bl6 mice were allocated to a sham control group, OVX, and OVX plus E2 treatment group for 8 weeks. Decreased bone mass including BMD and BMC were found in the OVX group compared with the sham control (p 
ISSN:2473-4039
2473-4039
DOI:10.1002/jbm4.10376