Elucidation of the mechanisms of exercise-induced hypoalgesia and pain prolongation due to physical stress and the restriction of movement

•Moderate exercise can activate the mesolimbic dopaminergic network.•Activation of the brain reward circuits is critical for exercise-induced hypoalgesia.•Moderate exercise recovers stress-induced physical and emotional disturbance. Persistent pain signals cause brain dysfunction and can further pro...

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Bibliographic Details
Published in:Neurobiology of pain 2023-08, Vol.14, p.100133-100133, Article 100133
Main Authors: Tanaka, Kenichi, Kuzumaki, Naoko, Hamada, Yusuke, Suda, Yukari, Mori, Tomohisa, Nagumo, Yasuyuki, Narita, Minoru
Format: Article
Language:English
Subjects:
Brain reward system
Exercise-induced hypoalgesia
Mesolimbic dopaminergic network
Mini Review
Pain prolongation
Stress
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Summary:•Moderate exercise can activate the mesolimbic dopaminergic network.•Activation of the brain reward circuits is critical for exercise-induced hypoalgesia.•Moderate exercise recovers stress-induced physical and emotional disturbance. Persistent pain signals cause brain dysfunction and can further prolong pain. In addition, the physical restriction of movement (e.g., by a cast) can cause stress and prolong pain. Recently, it has been recognized that exercise therapy including rehabilitation is effective for alleviating chronic pain. On the other hand, physical stress and the restriction of movement can prolong pain. In this review, we discuss the neural circuits involved in the control of pain prolongation and the mechanisms of exercise-induced hypoalgesia (EIH). We also discuss the importance of the mesolimbic dopaminergic network in these phenomena.
ISSN:2452-073X
2452-073X
DOI:10.1016/j.ynpai.2023.100133