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Expression and clinicopathologic significance of human achaete-scute homolog 1 in pulmonary neuroendocrine tumors
Human achaete-scute homolog 1 (hASH1) gene plays a critical role in development of the central nervous system, automatic nervous system, adrenal medullary chromaffin cells, thyroid C cells and pulmonary neuroendocrine cells. The aim of this study is to determine hASH1 gene expression in the normal l...
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| Published in: | Zhongguo fei ai za zhi 2010-04, Vol.13 (4), p.317-321 |
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| container_end_page | 321 |
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| container_title | Zhongguo fei ai za zhi |
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| creator | Li, Fei Zhong, Zhiyong Li, Rui Huang, Heyu Wang, Lijun Zheng, Donghan Zhang, Daorong |
| description | Human achaete-scute homolog 1 (hASH1) gene plays a critical role in development of the central nervous system, automatic nervous system, adrenal medullary chromaffin cells, thyroid C cells and pulmonary neuroendocrine cells. The aim of this study is to determine hASH1 gene expression in the normal lung tissue and various types of lung tumors, to analyze whether its expression correlated with pulmonary neuroendocrine markers, and to explore the possibility of hASH1 as clinical pathological markers in the neuroendocrine tumors compared with previous neuroendocrine tumor markers.
hASH1, Chromogranin A, Synaptophysin and CD56 expression were examined in lung tumor specimens (lung inflammatory pseudotumor, squamous cell carcinoma, adenocarcinomas, large cell carcinoma, typical carcinoids, atypical carcinoids, large cell neuroendocrine carcinomas and small cell lung carcinoma and corresponding normal lung specimens) using immunohistochemistry (S-P method). Western blot and reverse transcription polymerase chain rea |
| doi_str_mv | 10.3779/j.issn.1009-3419.2010.04.09 |
| format | article |
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hASH1, Chromogranin A, Synaptophysin and CD56 expression were examined in lung tumor specimens (lung inflammatory pseudotumor, squamous cell carcinoma, adenocarcinomas, large cell carcinoma, typical carcinoids, atypical carcinoids, large cell neuroendocrine carcinomas and small cell lung carcinoma and corresponding normal lung specimens) using immunohistochemistry (S-P method). Western blot and reverse transcription polymerase chain rea</description><identifier>ISSN: 1009-3419</identifier><identifier>EISSN: 1999-6187</identifier><identifier>DOI: 10.3779/j.issn.1009-3419.2010.04.09</identifier><identifier>PMID: 20677557</identifier><language>chi</language><publisher>China: Chinese Anti-Cancer Association; Chinese Antituberculosis Association</publisher><subject>Adenocarcinoma - genetics ; Adenocarcinoma - metabolism ; Adenocarcinoma - pathology ; Basic Helix-Loop-Helix Transcription Factors - genetics ; Basic Helix-Loop-Helix Transcription Factors - metabolism ; Carcinoma, Large Cell - genetics ; Carcinoma, Large Cell - metabolism ; Carcinoma, Large Cell - pathology ; Carcinoma, Neuroendocrine - genetics ; Carcinoma, Neuroendocrine - metabolism ; Carcinoma, Neuroendocrine - pathology ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - pathology ; Gene Expression Regulation, Neoplastic - genetics ; Gene Expression Regulation, Neoplastic - physiology ; Human achaete-scute homolog 1 ; Humans ; Immunohistochemistry ; Lung neoplasms ; Lung Neoplasms - genetics ; Lung Neoplasms - metabolism ; Lung Neoplasms - pathology ; Lung neuroendocrine neoplasms ; Neuroendocrine Tumors - genetics ; Neuroendocrine Tumors - metabolism ; Neuroendocrine Tumors - pathology ; Reverse Transcriptase Polymerase Chain Reaction ; Small Cell Lung Carcinoma - genetics ; Small Cell Lung Carcinoma - metabolism ; Small Cell Lung Carcinoma - pathology ; Tumor markers</subject><ispartof>Zhongguo fei ai za zhi, 2010-04, Vol.13 (4), p.317-321</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923,37011</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20677557$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Fei</creatorcontrib><creatorcontrib>Zhong, Zhiyong</creatorcontrib><creatorcontrib>Li, Rui</creatorcontrib><creatorcontrib>Huang, Heyu</creatorcontrib><creatorcontrib>Wang, Lijun</creatorcontrib><creatorcontrib>Zheng, Donghan</creatorcontrib><creatorcontrib>Zhang, Daorong</creatorcontrib><title>Expression and clinicopathologic significance of human achaete-scute homolog 1 in pulmonary neuroendocrine tumors</title><title>Zhongguo fei ai za zhi</title><addtitle>Zhongguo Fei Ai Za Zhi</addtitle><description>Human achaete-scute homolog 1 (hASH1) gene plays a critical role in development of the central nervous system, automatic nervous system, adrenal medullary chromaffin cells, thyroid C cells and pulmonary neuroendocrine cells. The aim of this study is to determine hASH1 gene expression in the normal lung tissue and various types of lung tumors, to analyze whether its expression correlated with pulmonary neuroendocrine markers, and to explore the possibility of hASH1 as clinical pathological markers in the neuroendocrine tumors compared with previous neuroendocrine tumor markers.
hASH1, Chromogranin A, Synaptophysin and CD56 expression were examined in lung tumor specimens (lung inflammatory pseudotumor, squamous cell carcinoma, adenocarcinomas, large cell carcinoma, typical carcinoids, atypical carcinoids, large cell neuroendocrine carcinomas and small cell lung carcinoma and corresponding normal lung specimens) using immunohistochemistry (S-P method). Western blot and reverse transcription polymerase chain rea</description><subject>Adenocarcinoma - genetics</subject><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - pathology</subject><subject>Basic Helix-Loop-Helix Transcription Factors - genetics</subject><subject>Basic Helix-Loop-Helix Transcription Factors - metabolism</subject><subject>Carcinoma, Large Cell - genetics</subject><subject>Carcinoma, Large Cell - metabolism</subject><subject>Carcinoma, Large Cell - pathology</subject><subject>Carcinoma, Neuroendocrine - genetics</subject><subject>Carcinoma, Neuroendocrine - metabolism</subject><subject>Carcinoma, Neuroendocrine - pathology</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Gene Expression Regulation, Neoplastic - genetics</subject><subject>Gene Expression Regulation, Neoplastic - physiology</subject><subject>Human achaete-scute homolog 1</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lung neoplasms</subject><subject>Lung Neoplasms - genetics</subject><subject>Lung Neoplasms - metabolism</subject><subject>Lung Neoplasms - pathology</subject><subject>Lung neuroendocrine neoplasms</subject><subject>Neuroendocrine Tumors - genetics</subject><subject>Neuroendocrine Tumors - metabolism</subject><subject>Neuroendocrine Tumors - pathology</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Small Cell Lung Carcinoma - genetics</subject><subject>Small Cell Lung Carcinoma - metabolism</subject><subject>Small Cell Lung Carcinoma - pathology</subject><subject>Tumor markers</subject><issn>1009-3419</issn><issn>1999-6187</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNo9kEtr3TAQRkVoSdIkf6EIsujKrl6WrGUJSXoh0E27NqPXvbrYkiPZkPz7OK-uZpg5nBk-hK4pablS-uexjbWmlhKiGy6obhnZVkS0RJ-gc6q1biTt1Zet_0TO0Ldaj4RIprk4RWeMSKW6Tp2jx9unufhaY04YksN2jCnaPMNyyGPeR4tr3KcYooVkPc4BH9YJNtYewC--qXZdPD7k6ZXGFMeE53WccoLyjJNfS_bJZVti8nhZp1zqJfoaYKz-6qNeoH93t39vfjcPf-53N78eGkc1XRrJjLSdNp12jFIhleyCM8GCBOZZzwC48bQnjASmrLBB8NB1nsie845ZzS_Q7t3rMhyHucRpe2nIEIe3QS77AcoS7eiHnmoCmkMwm8k4a4A45l5jNZufs8314901l_y4-roMU6zWjyMkn9c6KNFrxYUWG_n9g1zN5N3_u5-J8xeETofS</recordid><startdate>201004</startdate><enddate>201004</enddate><creator>Li, Fei</creator><creator>Zhong, Zhiyong</creator><creator>Li, Rui</creator><creator>Huang, Heyu</creator><creator>Wang, Lijun</creator><creator>Zheng, Donghan</creator><creator>Zhang, Daorong</creator><general>Chinese Anti-Cancer Association; Chinese Antituberculosis Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>DOA</scope></search><sort><creationdate>201004</creationdate><title>Expression and clinicopathologic significance of human achaete-scute homolog 1 in pulmonary neuroendocrine tumors</title><author>Li, Fei ; Zhong, Zhiyong ; Li, Rui ; Huang, Heyu ; Wang, Lijun ; Zheng, Donghan ; Zhang, Daorong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-d191t-62b6c59b59d21146765fdbfca6a2e282aa3be18020f27c4cf43f55e0683352c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2010</creationdate><topic>Adenocarcinoma - genetics</topic><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - pathology</topic><topic>Basic Helix-Loop-Helix Transcription Factors - genetics</topic><topic>Basic Helix-Loop-Helix Transcription Factors - metabolism</topic><topic>Carcinoma, Large Cell - genetics</topic><topic>Carcinoma, Large Cell - metabolism</topic><topic>Carcinoma, Large Cell - pathology</topic><topic>Carcinoma, Neuroendocrine - genetics</topic><topic>Carcinoma, Neuroendocrine - metabolism</topic><topic>Carcinoma, Neuroendocrine - pathology</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Gene Expression Regulation, Neoplastic - genetics</topic><topic>Gene Expression Regulation, Neoplastic - physiology</topic><topic>Human achaete-scute homolog 1</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lung neoplasms</topic><topic>Lung Neoplasms - genetics</topic><topic>Lung Neoplasms - metabolism</topic><topic>Lung Neoplasms - pathology</topic><topic>Lung neuroendocrine neoplasms</topic><topic>Neuroendocrine Tumors - genetics</topic><topic>Neuroendocrine Tumors - metabolism</topic><topic>Neuroendocrine Tumors - pathology</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Small Cell Lung Carcinoma - genetics</topic><topic>Small Cell Lung Carcinoma - metabolism</topic><topic>Small Cell Lung Carcinoma - pathology</topic><topic>Tumor markers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Fei</creatorcontrib><creatorcontrib>Zhong, Zhiyong</creatorcontrib><creatorcontrib>Li, Rui</creatorcontrib><creatorcontrib>Huang, Heyu</creatorcontrib><creatorcontrib>Wang, Lijun</creatorcontrib><creatorcontrib>Zheng, Donghan</creatorcontrib><creatorcontrib>Zhang, Daorong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>DOAJÂ Directory of Open Access Journals</collection><jtitle>Zhongguo fei ai za zhi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Fei</au><au>Zhong, Zhiyong</au><au>Li, Rui</au><au>Huang, Heyu</au><au>Wang, Lijun</au><au>Zheng, Donghan</au><au>Zhang, Daorong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression and clinicopathologic significance of human achaete-scute homolog 1 in pulmonary neuroendocrine tumors</atitle><jtitle>Zhongguo fei ai za zhi</jtitle><addtitle>Zhongguo Fei Ai Za Zhi</addtitle><date>2010-04</date><risdate>2010</risdate><volume>13</volume><issue>4</issue><spage>317</spage><epage>321</epage><pages>317-321</pages><issn>1009-3419</issn><eissn>1999-6187</eissn><abstract>Human achaete-scute homolog 1 (hASH1) gene plays a critical role in development of the central nervous system, automatic nervous system, adrenal medullary chromaffin cells, thyroid C cells and pulmonary neuroendocrine cells. The aim of this study is to determine hASH1 gene expression in the normal lung tissue and various types of lung tumors, to analyze whether its expression correlated with pulmonary neuroendocrine markers, and to explore the possibility of hASH1 as clinical pathological markers in the neuroendocrine tumors compared with previous neuroendocrine tumor markers.
hASH1, Chromogranin A, Synaptophysin and CD56 expression were examined in lung tumor specimens (lung inflammatory pseudotumor, squamous cell carcinoma, adenocarcinomas, large cell carcinoma, typical carcinoids, atypical carcinoids, large cell neuroendocrine carcinomas and small cell lung carcinoma and corresponding normal lung specimens) using immunohistochemistry (S-P method). Western blot and reverse transcription polymerase chain rea</abstract><cop>China</cop><pub>Chinese Anti-Cancer Association; Chinese Antituberculosis Association</pub><pmid>20677557</pmid><doi>10.3779/j.issn.1009-3419.2010.04.09</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Zhongguo fei ai za zhi, 2010-04, Vol.13 (4), p.317-321 |
| issn | 1009-3419 1999-6187 |
| language | chi |
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| source | Publicly Available Content Database (Proquest) (PQ_SDU_P3); PubMed Central (Open access) |
| subjects | Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - pathology Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Carcinoma, Large Cell - genetics Carcinoma, Large Cell - metabolism Carcinoma, Large Cell - pathology Carcinoma, Neuroendocrine - genetics Carcinoma, Neuroendocrine - metabolism Carcinoma, Neuroendocrine - pathology Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Gene Expression Regulation, Neoplastic - genetics Gene Expression Regulation, Neoplastic - physiology Human achaete-scute homolog 1 Humans Immunohistochemistry Lung neoplasms Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Lung neuroendocrine neoplasms Neuroendocrine Tumors - genetics Neuroendocrine Tumors - metabolism Neuroendocrine Tumors - pathology Reverse Transcriptase Polymerase Chain Reaction Small Cell Lung Carcinoma - genetics Small Cell Lung Carcinoma - metabolism Small Cell Lung Carcinoma - pathology Tumor markers |
| title | Expression and clinicopathologic significance of human achaete-scute homolog 1 in pulmonary neuroendocrine tumors |
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