Free iron accumulation and oxidative stress burden induce ferroptotic atrophy of chicken yolk sac during the late embryogenesis

The aim of this study was to investigate the mechanism of iron homeostasis and the ferroptosis pathway for yolk sac atrophy during late embryogenesis. To study the mechanism of yolk sac atrophy, 100 eggs were used. Further, 500 eggs were randomly divided into five treatments and in ovo feeding with...

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Bibliographic Details
Published in:Animal research and one health 2024-08, Vol.2 (3), p.285-299
Main Authors: Liu, Huichao, Song, Zehe, He, Xi, Zhang, Haihan
Format: Article
Language:English
Subjects:
chicken embryo
ferroptosis
in ovo feeding
iron homeostasis
yolk sac
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Summary:The aim of this study was to investigate the mechanism of iron homeostasis and the ferroptosis pathway for yolk sac atrophy during late embryogenesis. To study the mechanism of yolk sac atrophy, 100 eggs were used. Further, 500 eggs were randomly divided into five treatments and in ovo feeding with different iron sources, such as FeSO4, ferrous glycinate (Fe‐Gly), or deferoxamine (DFO), to study the effects of free iron content on hatching quality and embryonic development. The results showed that total iron content of yolk decreased, but yolk sac increased from embryonic(E)13 to E19 (p 
ISSN:2835-5075
2835-5075
DOI:10.1002/aro2.74