Three New Sesquiterpene Glycosides from the Rhizomes of Trillium tschonoskii

• Published in: Molecules (Basel, Switzerland) Switzerland), 2017-08, Vol.22 (8), p.1283
• Main Authors: Yang, Jie, Yang, Yin-Jun, Sun, Xin-Guang, Zhang, Jie, Zhao, Yang, Wang, Bei, Ding, Qian-Zhi, Guo, Bao-Lin, Ma, Bai-Ping
• Format: Article
• Language: English
• Subjects: Carbon; Cell Survival - drug effects; Chinese medicine; Cytotoxicity; Drug Discovery; Experiments; Glycosides; Glycosides - chemistry; Glycosides - pharmacology; Glycosides - toxicity; Hepatocytes - cytology; Hepatocytes - drug effects; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; NMR; Nuclear magnetic resonance; Plant Extracts - chemistry; Rhizome - chemistry; Rhizomes; separation; sesquiterpene glycosides; Sesquiterpenes - chemistry; Sesquiterpenes - pharmacology; Sesquiterpenes - toxicity; Spectrometry, Mass, Electrospray Ionization; Trillium - chemistry; Trillium tschonoskii
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules22081283

Three new sesquiterpene glycosides, possessing a rare aglycone with a sulfonyl between C-1 and C-15 positions, named 3-(3' -7' ,8'-dihydroxy-4',8'-dimethyl-3'-nonenyl)-2,5-dihydro-1,1-dioxo-thiophen 7'- -β-d-glucopyranosyl-(1→4)- -β-d-glucopyranosyl-(1→4)- -β-d-glucopyranoside ( ), 3-(3' -7' ,8'-dihydroxy-4',8'-dimethyl-3'-nonenyl)-2,5-dihydro-1,1-dioxo-thiophen 7'- -β-d-glucopyranosyl-(1→4)- -β-d-glucopyranoside ( ), and 3-(3' -7' ,8'-dihydroxy-4',8'-dimethyl-3'-nonenyl)-2,5-dihydro-1,1-dioxo-thiophen 7'- -β-d-glucopyranosyl-6'- -acetyl-(1→4)- -β-d-glucopyranosyl-(1→4)- -β-d-glucopyranoside ( ), respectively, were isolated from the rhizomes of . Their structures were established on the basis of spectroscopic data, including HR-ESI-MS, IR, 1D and 2D NMR. The cytotoxic properties of the three compounds were investigated using human hepatic L02 cells.