Progressive Metabolic Dysfunction and Nutritional Variability Precedes Necrotizing Enterocolitis

Necrotizing Enterocolitis (NEC) is associated with prematurity, enteral feedings, and enteral dysbiosis. Accordingly, we hypothesized that along with nutritional variability, metabolic dysfunction would be associated with NEC onset. We queried a multicenter longitudinal database that included 995 pr...

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Bibliographic Details
Published in:Nutrients 2020-04, Vol.12 (5), p.1275
Main Authors: Sinclair, Tiffany J, Ye, Chengyin, Chen, Yunliang, Zhang, Dongyan, Li, Tian, Ling, Xuefeng Bruce, Cohen, Harvey J, Shaw, Gary M, Stevenson, David K, Chace, Donald, Clark, Reese H, Sylvester, Karl G
Format: Article
Language:English
Subjects:
Abnormalities
Alanine
Amino acids
Amino Acids - metabolism
Arginine
Birth
Birth weight
Breastfeeding & lactation
Calories
Cancer therapies
Carnitine
Citrulline
Confidence intervals
Data Analysis
Databases as Topic
Dysbacteriosis
Enterocolitis
Enterocolitis, Necrotizing - etiology
Enterocolitis, Necrotizing - prevention & control
Fatty acids
Female
Gastrointestinal diseases
Gestation
growth faltering
growth velocity
Humans
Infant Nutritional Physiological Phenomena - physiology
Infant, Newborn
Infant, Premature - metabolism
Infants
Inflammatory bowel disease
Longitudinal Studies
Male
Medical screening
Metabolic Diseases - etiology
Metabolic Diseases - metabolism
Metabolism
Metabolites
metabolomics
Multicenter Studies as Topic
Necrosis
Necrotizing enterocolitis
Neonates
Newborn babies
newborn calories
newborn metabolic profiling
Nutrition
Nutrition Disorders - etiology
Nutrition Disorders - metabolism
Nutritional Status
Phenylalanine
Variability
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Description
Summary:Necrotizing Enterocolitis (NEC) is associated with prematurity, enteral feedings, and enteral dysbiosis. Accordingly, we hypothesized that along with nutritional variability, metabolic dysfunction would be associated with NEC onset. We queried a multicenter longitudinal database that included 995 preterm infants (
ISSN:2072-6643
2072-6643
DOI:10.3390/nu12051275