Fibrinogen Dysregulation is a Prominent Process in Fatal Conditions of COVID-19 Infection; a Proteomic Analysis

Molecular pathophysiology of COVID-19 is not completely known. Expression changes in patients' plasma proteins have revealed new information about the disease. Introducing the key targeted plasma protein in fatal conditions of COVID-19 infection is the aim of this study. Significant differentia...

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Bibliographic Details
Published in:Archives of academic emergency medicine 2021-01, Vol.9 (1), p.e26-e26
Main Authors: Rezaei-Tavirani, Mostafa, Rostami Nejad, Mohammad, Arjmand, Babak, Rezaei Tavirani, Sina, Razzaghi, Mohammadreza, Mansouri, Vahid
Format: Article
Language:English
Subjects:
Fibrinogen
Original Research
Protein Interaction Maps
Proteins
Proteomics
SARS-CoV-2
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Summary:Molecular pathophysiology of COVID-19 is not completely known. Expression changes in patients' plasma proteins have revealed new information about the disease. Introducing the key targeted plasma protein in fatal conditions of COVID-19 infection is the aim of this study. Significant differentially expressed proteins (DEPs) in the plasma of cases with a fatal condition of COVID-19 were extracted from an original article. These proteins were included in a network via STRING database along with 100 first neighbor proteins to determine central nodes of the network for analyzing. Queried and added proteins were included in a scale free network. Three hub nodes were identified as critical target proteins. The top queried hub proteins were chains of fibrinogen; Fibrinogen Alpha chain (FGA), Fibrinogen gamma chain (FGG), and Fibrinogen beta chain (FGB), which are related to the coagulation process. It seems that fibrinogen dysregulation has a deep impact on the fatality of COVID-19 infection.
ISSN:2645-4904
DOI:10.22037/aaem.v9i1.1128