Generation of an induced pluripotent stem cell line (GIBHi003-A) from a Parkinson's disease patient with mutant PINK1 (p. I368N)

Familial Parkinson's disease (PD) can be caused by deleterious mutations in PINK1 (encoding PINK1) in an autosomal recessive manner. Functional studies suggest that PINK1 works as a regulator of mitochondrial homeostasis. However, how loss of PINK1 induces dopaminergic neuron degeneration is st...

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Published in:Stem cell research 2019-12, Vol.41, p.101607-101607, Article 101607
Main Authors: Abdul, Mazid Md, Ibañez, David P., Zhao, Ping, Liu, Hao, Zhong, Xiaofen, Li, Yingying, Zhang, Meng, Li, Wenjuan, Li, Yunpan, Ward, Carl, Chen, Shuhan, Wang, Dongye, Qin, Baoming, Esteban, Miguel A., Wang, Xiwei, Fan, Wenxia, Luo, Zhiwei
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container_end_page 101607
container_issue
container_start_page 101607
container_title Stem cell research
container_volume 41
creator Abdul, Mazid Md
Ibañez, David P.
Zhao, Ping
Liu, Hao
Zhong, Xiaofen
Li, Yingying
Zhang, Meng
Li, Wenjuan
Li, Yunpan
Ward, Carl
Chen, Shuhan
Wang, Dongye
Qin, Baoming
Esteban, Miguel A.
Wang, Xiwei
Fan, Wenxia
Luo, Zhiwei
description Familial Parkinson's disease (PD) can be caused by deleterious mutations in PINK1 (encoding PINK1) in an autosomal recessive manner. Functional studies suggest that PINK1 works as a regulator of mitochondrial homeostasis. However, how loss of PINK1 induces dopaminergic neuron degeneration is still unclear. Here, we have generated a patient-derived induced pluripotent stem cell (iPSC) line with mutant PINK1 (p. I368N). This cell line will facilitate PD disease modeling in vitro and can be used for generating isogenic cell lines through gene correction.
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title Generation of an induced pluripotent stem cell line (GIBHi003-A) from a Parkinson's disease patient with mutant PINK1 (p. I368N)
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