Prognostic impact of genetic characterization in the GIMEMA LAM99P multicenter study for newly diagnosed acute myeloid leukemia

Acute Leukemia Working Party of the GIMEMA group Correspondence: Francesco Lo-Coco, Department of Biopathology, University Tor Vergata, via Montpellier 1, 00161 Rome, Italy, E-mail: francesco.lo.coco{at}uniroma2.it Background: Recent advances in genetic characterization of acute myeloid leukemia ind...

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Published in:Haematologica (Roma) 2008-07, Vol.93 (7), p.1017-1024
Main Authors: Lo-Coco, Francesco, Cuneo, Antonio, Pane, Fabrizio, Cilloni, Daniela, Diverio, Daniela, Mancini, Marco, Testoni, Nicoletta, Bardi, Antonella, Izzo, Barbara, Bolli, Niccolo, La Starza, Roberta, Fazi, Paola, Iacobelli, Simona, Piciocchi, Alfonso, Vignetti, Marco, Amadori, Sergio, Mandelli, Franco, Pelicci, Pier Giuseppe, Mecucci, Cristina, Falini, Brunangelo, Saglio, Giuseppe, Acute Leukemia Working Party of GIMEMA group
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Cytogenetics
DNA Mutational Analysis
Genetic Markers
Hematologic and hematopoietic diseases
Humans
Italy
Karyotyping
Leukemia, Myeloid, Acute - diagnosis
Leukemia, Myeloid, Acute - genetics
Leukemia, Myeloid, Acute - therapy
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Medical sciences
Middle Aged
Multivariate Analysis
Mutation
Prognosis
Prospective Studies
Remission Induction
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Summary:Acute Leukemia Working Party of the GIMEMA group Correspondence: Francesco Lo-Coco, Department of Biopathology, University Tor Vergata, via Montpellier 1, 00161 Rome, Italy, E-mail: francesco.lo.coco{at}uniroma2.it Background: Recent advances in genetic characterization of acute myeloid leukemia indicate that combined cytogenetic and molecular analyses provide better definition of prognostic groups. The aim of this study was to verify this prospectively in a large group of patients. Design and Methods: Genetic characterization was prospectively carried out in 397 patients with acute myeloid leukemia (median age, 46 years) receiving uniform treatment according to the LAM99P protocol of the Italian GIMEMA group. The impact of genetic markers on response to therapy and outcome was assessed by univariate and multivariate analyses. Results: For induction response, conventional karyotyping identified three groups with complete remission rates of 92%, 67% and 39% ( p
ISSN:0390-6078
1592-8721
DOI:10.3324/haematol.12004