Synthesis and Antimicrobial Evaluation of 2-[2-(9H-Fluoren-9-ylidene)hydrazin-1-yl]-1,3-thiazole Derivatives

Fluorenyl-hydrazonothiazole derivatives 2–7 were synthesized by the Hantzsch reaction from 2-(9H-fluoren-9-ylidene)hydrazine-1-carbothioamide (1) and the corresponding α-halocarbonyl compounds in THF or 1,4-dioxane solvent. A base catalyst is not necessary for synthesising thiazoles, but it can shor...

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Bibliographic Details
Published in:MolBank 2024-09, Vol.2024 (3), p.M1872
Main Authors: Anusevičius, Kazimieras, Stebrytė, Ignė, Kavaliauskas, Povilas
Format: Article
Language:English
Subjects:
Acids
Analysis
antibacterial
Antibiotics
antifungal
Antimicrobial agents
carbothioamide
Chemical synthesis
Dioxane
Drug resistance
Fluorene
fluorenone
Gram-positive bacteria
Hydrazines
Identification and classification
Methods
Nitrogen
Pathogens
Properties
Sodium
Solvents
Thiazoles
Virulence
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Summary:Fluorenyl-hydrazonothiazole derivatives 2–7 were synthesized by the Hantzsch reaction from 2-(9H-fluoren-9-ylidene)hydrazine-1-carbothioamide (1) and the corresponding α-halocarbonyl compounds in THF or 1,4-dioxane solvent. A base catalyst is not necessary for synthesising thiazoles, but it can shorten the reaction time. The antimicrobial properties of all synthesized compounds were screened for multidrug-resistant microorganism strains. The minimum inhibitory concentration of the tested compounds against Gram-positive bacteria and fungi was higher than 256 μg/mL, but several compounds had activity against Gram-positive strains.
ISSN:1422-8599
1422-8599
DOI:10.3390/M1872