Storming the castle: A case report of multi‐system dysregulation in a child with Castleman disease

Castleman disease is a non‐clonal, lymphoproliferative disorder rarely seen in children. Presented is a 12‐year‐old male with progressive abdominal pain, vomiting, and fever. Diagnostic testing revealed multi‐organ system involvement and the diagnosis was ultimately made with tissue biopsy. Marked d...

Full description

Saved in:
Bibliographic Details
Published in:Clinical case reports 2022-02, Vol.10 (2), p.e05491-n/a
Main Authors: DeMarsh, Samantha J., Kendel, Nicole E., Bacha, Christine, Ardoin, Stacy P., Kahwash, Samir, Rose, Melissa J.
Format: Article
Language:English
Subjects:
Abdomen
Anemia
angiofollicular
Antibodies
Biopsy
Bone marrow
Case Report
Case Reports
Castleman
Cytokines
Fever
Histopathology
Hyperplasia
Hypertension
Hypocalcemia
Hypothyroidism
interleukin‐6
Laboratories
Lymphatic system
Lymphocytes
lymphoproliferative
Magnetic resonance imaging
Thrombocytopenia
Tomography
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Castleman disease is a non‐clonal, lymphoproliferative disorder rarely seen in children. Presented is a 12‐year‐old male with progressive abdominal pain, vomiting, and fever. Diagnostic testing revealed multi‐organ system involvement and the diagnosis was ultimately made with tissue biopsy. Marked disease regression occurred after high‐dose steroids and continued interleukin‐6 inhibition. Given the diagnostic complexity and multi‐system organ involvement of Castleman disease, awareness of the clinical presentation in a pediatric patient is important. This can prevent delayed diagnosis and provide timely, life‐saving care.
ISSN:2050-0904
2050-0904
DOI:10.1002/ccr3.5491