Efficacy and safety of tranexamic acid use in elderly patients undergoing anterior cervical discectomy and fusion: a retrospective study

• Published in: Journal of international medical research 2024-09, Vol.52 (9), p.3000605241285661
• Main Authors: Lou, Zhenqi, Jiang, Yi, Jiang, Kanling, Zhu, Jieyang, Lai, Lan, Huang, Zhihai, Zhu, Jinyu
• Format: Article
• Language: English
• Subjects: Administration, Intravenous; Aged; Aged, 80 and over; Antifibrinolytic Agents - administration & dosage; Antifibrinolytic Agents - adverse effects; Antifibrinolytic Agents - therapeutic use; Blood Loss, Surgical - prevention & control; Cervical Vertebrae - surgery; Diskectomy - adverse effects; Diskectomy - methods; Female; Hemoglobin; Humans; Length of Stay; Male; Observational Study; Operative Time; Retrospective Studies; Spinal Fusion - adverse effects; Spinal Fusion - methods; Spondylosis - surgery; Tranexamic Acid - administration & dosage; Tranexamic Acid - adverse effects; Tranexamic Acid - therapeutic use; Treatment Outcome
• ISSN: 0300-0605; 1473-2300; 1473-2300
• DOI: 10.1177/03000605241285661

Objective To evaluate the safety and efficacy of intravenous tranexamic acid (TXA) administration in anterior cervical discectomy fusion (ACDF) for the treatment of cervical spondylosis in the elderly. Methods Data from elderly patients who underwent ACDF between January 2020 and January 2023 were retrospectively reviewed. Patients who received 1 g intravenous TXA administration before skin incision (TXA group) were compared with patients who did not receive TXA (controls). Total and hidden blood loss were calculated, and the following outcomes were recorded: haemoglobin and haematocrit drop, operation time, drainage duration, drain volume, length of hospitalization, coagulation changes, and incidence of complications. Results A total of 114 patients were included (TXA group, n = 53 and controls, n = 61). Total blood loss, hidden blood loss, and postoperative drainage volume, haemoglobin and haematocrit drop were significantly lower in the TXA group than the control group. There were no significant differences in operation time, intraoperative blood loss, drainage duration, length of hospitalization, or coagulation function between the two groups. The incidence of complications did not differ significantly between the two groups during 3 months of follow-up. Conclusions Intravenous TXA is effective in reducing perioperative blood loss in elderly patients undergoing ACDF without changing the coagulation function or increasing the risk of complications.