Bio-Repository of DNA in stroke (BRAINS): a study protocol

Stroke is one of the commonest causes of mortality in the world and anticipated to be an increasing burden to the developing world. Stroke has a genetic basis and identifying those genes may not only help us define the mechanisms that cause stroke but also identify novel therapeutic targets. However...

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Bibliographic Details
Published in:BMC genetics 2011-03, Vol.12 (1), p.34-34, Article 34
Main Authors: Yadav, Sunaina, Schanz, Renata, Maheshwari, Ankita, Khan, Muhammad Saleem, Slark, Julia, de Silva, Ranil, Bentley, Paul, Froguel, Philippe, Kooner, Jaspal, Shrivastav, Padma, Prasad, Kameshwar, Sharma, Pankaj
Format: Article
Language:English
Subjects:
Asian people
Biological Specimen Banks
Brain research
Disease
DNA - chemistry
Ethics
Genes
Genetic aspects
Genome-Wide Association Study
Genomes
Genomic libraries
Genomics
Health risk assessment
Humans
Hypertension
Ischemia
Minority & ethnic groups
Patients
Phenotype
Risk Factors
Stroke
Stroke (Disease)
Stroke - ethnology
Stroke - genetics
Study Protocol
White people
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Summary:Stroke is one of the commonest causes of mortality in the world and anticipated to be an increasing burden to the developing world. Stroke has a genetic basis and identifying those genes may not only help us define the mechanisms that cause stroke but also identify novel therapeutic targets. However, large scale highly phenotyped DNA repositories are required in order for this to be achieved. The proposed Bio-Repository of DNA in Stroke (BRAINS) will recruit all subtypes of stroke as well as controls from two different continents, Europe and Asia. Subjects recruited from the UK will include stroke patients of European ancestry as well as British South Asians. Stroke subjects from South Asia will be recruited from India and Sri Lanka. South Asian cases will also have control subjects recruited. We describe a study protocol to establish a large and highly characterized stroke biobank in those of European and South Asian descent. With different ethnic populations being recruited, BRAINS has the ability to compare and contrast genetic risk factors between those of differing ancestral descent as well as those who migrate into different environments.
ISSN:1471-2350
1471-2156
1471-2350
1471-2156
DOI:10.1186/1471-2350-12-34