Metabolomic Analysis in Neurocritical Care Patients

Metabolomics is the analytical study of metabolites in biological matrices using high-throughput profiling. Traditionally, the metabolome has been studied to identify various biomarkers for the diagnosis and pathophysiology of disease. Over the last decade, metabolomic research has grown to include...

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Bibliographic Details
Published in:Metabolites 2023-06, Vol.13 (6), p.745
Main Authors: Kharouba, Maged, Patel, Dimple D, Jaber, Rami H, Mahmoud, Sherif Hanafy
Format: Article
Language:English
Subjects:
Amino acids
Analysis
Aneurysm
Biomarkers
Brain research
Care and treatment
Cerebrospinal fluid
Clinical outcomes
Cohort analysis
Critically ill
Diagnosis
Hemorrhage
Information management
intracerebral hemorrhage
Metabolism
Metabolites
Metabolomics
neurocritical care
Neurology
NMR
Nuclear magnetic resonance
Palliative treatment
Pathophysiology
Patients
Review
Stroke
Subarachnoid hemorrhage
Traumatic brain injury
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Summary:Metabolomics is the analytical study of metabolites in biological matrices using high-throughput profiling. Traditionally, the metabolome has been studied to identify various biomarkers for the diagnosis and pathophysiology of disease. Over the last decade, metabolomic research has grown to include the identification of prognostic markers, the development of novel treatment strategies, and the prediction of disease severity. In this review, we summarized the available evidence on the use of metabolome profiling in neurocritical care populations. Specifically, we focused on aneurysmal subarachnoid hemorrhage, traumatic brain injury, and intracranial hemorrhage to identify the gaps in the current literature and to provide direction for future studies. A primary literature search of the Medline and EMBASE databases was conducted. Upon removing duplicate studies, abstract screening and full-text screening were performed. We screened 648 studies and extracted data from 17 studies. Based on the current evidence, the utility of metabolomic profiling has been limited due to inconsistencies amongst studies and a lack of reproducible data. Studies identified various biomarkers for diagnosis, prognosis, and treatment modification. However, studies evaluated and identified different metabolites, resulting in an inability to compare the study results. Future research towards addressing the gaps in the current literature, including reproducing data on the use of specific metabolite panels, is needed.
ISSN:2218-1989
2218-1989
DOI:10.3390/metabo13060745