Snake venom disintegrins and cell migration

Cell migration is a key process for the defense of pluricellular organisms against pathogens, and it involves a set of surface receptors acting in an ordered fashion to contribute directionality to the movement. Among these receptors are the integrins, which connect the cell cytoskeleton to the extr...

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Bibliographic Details
Published in:Toxins 2010-11, Vol.2 (11), p.2606-2621
Main Authors: Selistre-de-Araujo, Heloisa S, Pontes, Carmen L S, Montenegro, Cyntia F, Martin, Ana Carolina B M
Format: Article
Language:English
Subjects:
ADAM
Animals
Anoikis - drug effects
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Antineoplastic Agents - pharmacology
Cell Adhesion - drug effects
cell migration
Cell Movement - drug effects
disintegrin
Disintegrins - antagonists & inhibitors
Disintegrins - toxicity
Humans
Neoplasm Metastasis - drug therapy
Neovascularization, Physiologic - drug effects
Neutrophils - drug effects
Review
snake venom
Snake Venoms - chemistry
Snake Venoms - pharmacology
Snakes
αvβ3 integrin
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Summary:Cell migration is a key process for the defense of pluricellular organisms against pathogens, and it involves a set of surface receptors acting in an ordered fashion to contribute directionality to the movement. Among these receptors are the integrins, which connect the cell cytoskeleton to the extracellular matrix components, thus playing a central role in cell migration. Integrin clustering at focal adhesions drives actin polymerization along the cell leading edge, resulting in polarity of cell movement. Therefore, small integrin-binding proteins such as the snake venom disintegrins that inhibit integrin-mediated cell adhesion are expected to inhibit cell migration. Here we review the current knowledge on disintegrin and disintegrin-like protein effects on cell migration and their potential use as pharmacological tools in anti-inflammatory therapy as well as in inhibition of metastatic invasion.
ISSN:2072-6651
2072-6651
DOI:10.3390/toxins2112606