Loading…
Bioactive Secondary Metabolites from Octocoral-Associated Microbes-New Chances for Blue Growth
Octocorals (Cnidaria, Anthozoa Octocorallia) are magnificent repositories of natural products with fascinating and unusual chemical structures and bioactivities of interest to medicine and biotechnology. However, mechanistic understanding of the contribution of microbial symbionts to the chemical di...
Saved in:
| Published in: | Marine drugs 2018-12, Vol.16 (12), p.485 |
|---|---|
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c4535-196a84d539e79816b181e8fc639ae41b6455941b540072a0e05699fefb9185043 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c4535-196a84d539e79816b181e8fc639ae41b6455941b540072a0e05699fefb9185043 |
| container_end_page | |
| container_issue | 12 |
| container_start_page | 485 |
| container_title | Marine drugs |
| container_volume | 16 |
| creator | Raimundo, Inês Silva, Sandra G Costa, Rodrigo Keller-Costa, Tina |
| description | Octocorals (Cnidaria, Anthozoa Octocorallia) are magnificent repositories of natural products with fascinating and unusual chemical structures and bioactivities of interest to medicine and biotechnology. However, mechanistic understanding of the contribution of microbial symbionts to the chemical diversity of octocorals is yet to be achieved. This review inventories the natural products so-far described for octocoral-derived bacteria and fungi, uncovering a true chemical arsenal of terpenes, steroids, alkaloids, and polyketides with antibacterial, antifungal, antiviral, antifouling, anticancer, anti-inflammatory, and antimalarial activities of enormous potential for blue growth. Genome mining of 15 bacterial associates (spanning 12 genera) cultivated from
spp. resulted in the identification of 440 putative and classifiable secondary metabolite biosynthetic gene clusters (BGCs), encompassing varied terpene-, polyketide-, bacteriocin-, and nonribosomal peptide-synthase BGCs. This points towards a widespread yet uncharted capacity of octocoral-associated bacteria to synthetize a broad range of natural products. However, to extend our knowledge and foster the near-future laboratory production of bioactive compounds from (cultivatable and currently uncultivatable) octocoral symbionts, optimal blending between targeted metagenomics, DNA recombinant technologies, improved symbiont cultivation, functional genomics, and analytical chemistry are required. Such a multidisciplinary undertaking is key to achieving a sustainable response to the urgent industrial demand for novel drugs and enzyme varieties. |
| doi_str_mv | 10.3390/md16120485 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_81f7354cf171407fbf14e4d0f1c3d7e0</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_81f7354cf171407fbf14e4d0f1c3d7e0</doaj_id><sourcerecordid>2179225648</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4535-196a84d539e79816b181e8fc639ae41b6455941b540072a0e05699fefb9185043</originalsourceid><addsrcrecordid>eNpdkktv1DAQgCMEog-48ANQJC6oUsDjV-wLUruCUqmlB-CK5TjjrldJXOykFf8eL1tKy2msmU-fZsZTVa-AvGNMk_djDxIo4Uo8qfZBStKUdPv0wXuvOsh5QwgTSvPn1R4jAhRQsV_9OAnRujncYP0VXZx6m37VFzjbLg5hxlz7FMf60s3RxWSH5jjn6IKdsa8vgkuxw9x8wdt6tbaT2-Ix1SfDgvVpirfz-kX1zNsh48u7eFh9__Tx2-pzc355erY6Pm8cF0w0oKVVvBdMY6sVyK50h8o7ybRFDp3kQugSBSekpZYgEVJrj77ToATh7LA623n7aDfmOoWxzGGiDeZPIqYrY9Mc3IBGgW-Z4M5DC5y0vvPAkffEg2N9i6S4Puxc10s3Yu9wmsvkj6SPK1NYm6t4YyQDySkUwds7QYo_F8yzGUN2OAx2wrhkQ6HVlArJVUHf_Idu4pKmsipDhaKKAaNb6mhHlYXnnNDfNwPEbE_A_DuBAr9-2P49-vfP2W-Tp6qD</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2582831328</pqid></control><display><type>article</type><title>Bioactive Secondary Metabolites from Octocoral-Associated Microbes-New Chances for Blue Growth</title><source>Publicly Available Content (ProQuest)</source><source>PubMed Central</source><creator>Raimundo, Inês ; Silva, Sandra G ; Costa, Rodrigo ; Keller-Costa, Tina</creator><creatorcontrib>Raimundo, Inês ; Silva, Sandra G ; Costa, Rodrigo ; Keller-Costa, Tina</creatorcontrib><description>Octocorals (Cnidaria, Anthozoa Octocorallia) are magnificent repositories of natural products with fascinating and unusual chemical structures and bioactivities of interest to medicine and biotechnology. However, mechanistic understanding of the contribution of microbial symbionts to the chemical diversity of octocorals is yet to be achieved. This review inventories the natural products so-far described for octocoral-derived bacteria and fungi, uncovering a true chemical arsenal of terpenes, steroids, alkaloids, and polyketides with antibacterial, antifungal, antiviral, antifouling, anticancer, anti-inflammatory, and antimalarial activities of enormous potential for blue growth. Genome mining of 15 bacterial associates (spanning 12 genera) cultivated from
spp. resulted in the identification of 440 putative and classifiable secondary metabolite biosynthetic gene clusters (BGCs), encompassing varied terpene-, polyketide-, bacteriocin-, and nonribosomal peptide-synthase BGCs. This points towards a widespread yet uncharted capacity of octocoral-associated bacteria to synthetize a broad range of natural products. However, to extend our knowledge and foster the near-future laboratory production of bioactive compounds from (cultivatable and currently uncultivatable) octocoral symbionts, optimal blending between targeted metagenomics, DNA recombinant technologies, improved symbiont cultivation, functional genomics, and analytical chemistry are required. Such a multidisciplinary undertaking is key to achieving a sustainable response to the urgent industrial demand for novel drugs and enzyme varieties.</description><identifier>ISSN: 1660-3397</identifier><identifier>EISSN: 1660-3397</identifier><identifier>DOI: 10.3390/md16120485</identifier><identifier>PMID: 30518125</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Analytical chemistry ; Antibiotics ; Anticancer properties ; Antifouling substances ; Antiviral agents ; Bacteria ; Bacteriocins ; Bioactive compounds ; Biological activity ; biopharmaceuticals ; bioprospection ; Biosynthesis ; Biotechnology ; blue economy ; Clinical trials ; Consortia ; Coral reefs ; Deoxyribonucleic acid ; DNA ; Fungi ; Fungicides ; Gene clusters ; Genera ; Genomes ; gorgonians ; host–microbe interactions ; Inflammation ; Invertebrates ; Marine invertebrates ; Medicine ; Metabolites ; Metagenomics ; Microorganisms ; Natural products ; Polyketides ; Recombinants ; Review ; Secondary metabolites ; Steroid hormones ; Symbionts ; Terpenes</subject><ispartof>Marine drugs, 2018-12, Vol.16 (12), p.485</ispartof><rights>2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 by the authors. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4535-196a84d539e79816b181e8fc639ae41b6455941b540072a0e05699fefb9185043</citedby><cites>FETCH-LOGICAL-c4535-196a84d539e79816b181e8fc639ae41b6455941b540072a0e05699fefb9185043</cites><orcidid>0000-0002-4763-0662 ; 0000-0003-3702-9192 ; 0000-0002-5932-4101</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2582831328/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2582831328?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,74998</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30518125$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Raimundo, Inês</creatorcontrib><creatorcontrib>Silva, Sandra G</creatorcontrib><creatorcontrib>Costa, Rodrigo</creatorcontrib><creatorcontrib>Keller-Costa, Tina</creatorcontrib><title>Bioactive Secondary Metabolites from Octocoral-Associated Microbes-New Chances for Blue Growth</title><title>Marine drugs</title><addtitle>Mar Drugs</addtitle><description>Octocorals (Cnidaria, Anthozoa Octocorallia) are magnificent repositories of natural products with fascinating and unusual chemical structures and bioactivities of interest to medicine and biotechnology. However, mechanistic understanding of the contribution of microbial symbionts to the chemical diversity of octocorals is yet to be achieved. This review inventories the natural products so-far described for octocoral-derived bacteria and fungi, uncovering a true chemical arsenal of terpenes, steroids, alkaloids, and polyketides with antibacterial, antifungal, antiviral, antifouling, anticancer, anti-inflammatory, and antimalarial activities of enormous potential for blue growth. Genome mining of 15 bacterial associates (spanning 12 genera) cultivated from
spp. resulted in the identification of 440 putative and classifiable secondary metabolite biosynthetic gene clusters (BGCs), encompassing varied terpene-, polyketide-, bacteriocin-, and nonribosomal peptide-synthase BGCs. This points towards a widespread yet uncharted capacity of octocoral-associated bacteria to synthetize a broad range of natural products. However, to extend our knowledge and foster the near-future laboratory production of bioactive compounds from (cultivatable and currently uncultivatable) octocoral symbionts, optimal blending between targeted metagenomics, DNA recombinant technologies, improved symbiont cultivation, functional genomics, and analytical chemistry are required. Such a multidisciplinary undertaking is key to achieving a sustainable response to the urgent industrial demand for novel drugs and enzyme varieties.</description><subject>Analytical chemistry</subject><subject>Antibiotics</subject><subject>Anticancer properties</subject><subject>Antifouling substances</subject><subject>Antiviral agents</subject><subject>Bacteria</subject><subject>Bacteriocins</subject><subject>Bioactive compounds</subject><subject>Biological activity</subject><subject>biopharmaceuticals</subject><subject>bioprospection</subject><subject>Biosynthesis</subject><subject>Biotechnology</subject><subject>blue economy</subject><subject>Clinical trials</subject><subject>Consortia</subject><subject>Coral reefs</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Fungi</subject><subject>Fungicides</subject><subject>Gene clusters</subject><subject>Genera</subject><subject>Genomes</subject><subject>gorgonians</subject><subject>host–microbe interactions</subject><subject>Inflammation</subject><subject>Invertebrates</subject><subject>Marine invertebrates</subject><subject>Medicine</subject><subject>Metabolites</subject><subject>Metagenomics</subject><subject>Microorganisms</subject><subject>Natural products</subject><subject>Polyketides</subject><subject>Recombinants</subject><subject>Review</subject><subject>Secondary metabolites</subject><subject>Steroid hormones</subject><subject>Symbionts</subject><subject>Terpenes</subject><issn>1660-3397</issn><issn>1660-3397</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdkktv1DAQgCMEog-48ANQJC6oUsDjV-wLUruCUqmlB-CK5TjjrldJXOykFf8eL1tKy2msmU-fZsZTVa-AvGNMk_djDxIo4Uo8qfZBStKUdPv0wXuvOsh5QwgTSvPn1R4jAhRQsV_9OAnRujncYP0VXZx6m37VFzjbLg5hxlz7FMf60s3RxWSH5jjn6IKdsa8vgkuxw9x8wdt6tbaT2-Ix1SfDgvVpirfz-kX1zNsh48u7eFh9__Tx2-pzc355erY6Pm8cF0w0oKVVvBdMY6sVyK50h8o7ybRFDp3kQugSBSekpZYgEVJrj77ToATh7LA623n7aDfmOoWxzGGiDeZPIqYrY9Mc3IBGgW-Z4M5DC5y0vvPAkffEg2N9i6S4Puxc10s3Yu9wmsvkj6SPK1NYm6t4YyQDySkUwds7QYo_F8yzGUN2OAx2wrhkQ6HVlArJVUHf_Idu4pKmsipDhaKKAaNb6mhHlYXnnNDfNwPEbE_A_DuBAr9-2P49-vfP2W-Tp6qD</recordid><startdate>20181204</startdate><enddate>20181204</enddate><creator>Raimundo, Inês</creator><creator>Silva, Sandra G</creator><creator>Costa, Rodrigo</creator><creator>Keller-Costa, Tina</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T7</scope><scope>7TN</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H95</scope><scope>H99</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.F</scope><scope>L.G</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PCBAR</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-4763-0662</orcidid><orcidid>https://orcid.org/0000-0003-3702-9192</orcidid><orcidid>https://orcid.org/0000-0002-5932-4101</orcidid></search><sort><creationdate>20181204</creationdate><title>Bioactive Secondary Metabolites from Octocoral-Associated Microbes-New Chances for Blue Growth</title><author>Raimundo, Inês ; Silva, Sandra G ; Costa, Rodrigo ; Keller-Costa, Tina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4535-196a84d539e79816b181e8fc639ae41b6455941b540072a0e05699fefb9185043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Analytical chemistry</topic><topic>Antibiotics</topic><topic>Anticancer properties</topic><topic>Antifouling substances</topic><topic>Antiviral agents</topic><topic>Bacteria</topic><topic>Bacteriocins</topic><topic>Bioactive compounds</topic><topic>Biological activity</topic><topic>biopharmaceuticals</topic><topic>bioprospection</topic><topic>Biosynthesis</topic><topic>Biotechnology</topic><topic>blue economy</topic><topic>Clinical trials</topic><topic>Consortia</topic><topic>Coral reefs</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Fungi</topic><topic>Fungicides</topic><topic>Gene clusters</topic><topic>Genera</topic><topic>Genomes</topic><topic>gorgonians</topic><topic>host–microbe interactions</topic><topic>Inflammation</topic><topic>Invertebrates</topic><topic>Marine invertebrates</topic><topic>Medicine</topic><topic>Metabolites</topic><topic>Metagenomics</topic><topic>Microorganisms</topic><topic>Natural products</topic><topic>Polyketides</topic><topic>Recombinants</topic><topic>Review</topic><topic>Secondary metabolites</topic><topic>Steroid hormones</topic><topic>Symbionts</topic><topic>Terpenes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Raimundo, Inês</creatorcontrib><creatorcontrib>Silva, Sandra G</creatorcontrib><creatorcontrib>Costa, Rodrigo</creatorcontrib><creatorcontrib>Keller-Costa, Tina</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Oceanic Abstracts</collection><collection>Proquest Health & Medical Complete</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Marine drugs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Raimundo, Inês</au><au>Silva, Sandra G</au><au>Costa, Rodrigo</au><au>Keller-Costa, Tina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bioactive Secondary Metabolites from Octocoral-Associated Microbes-New Chances for Blue Growth</atitle><jtitle>Marine drugs</jtitle><addtitle>Mar Drugs</addtitle><date>2018-12-04</date><risdate>2018</risdate><volume>16</volume><issue>12</issue><spage>485</spage><pages>485-</pages><issn>1660-3397</issn><eissn>1660-3397</eissn><abstract>Octocorals (Cnidaria, Anthozoa Octocorallia) are magnificent repositories of natural products with fascinating and unusual chemical structures and bioactivities of interest to medicine and biotechnology. However, mechanistic understanding of the contribution of microbial symbionts to the chemical diversity of octocorals is yet to be achieved. This review inventories the natural products so-far described for octocoral-derived bacteria and fungi, uncovering a true chemical arsenal of terpenes, steroids, alkaloids, and polyketides with antibacterial, antifungal, antiviral, antifouling, anticancer, anti-inflammatory, and antimalarial activities of enormous potential for blue growth. Genome mining of 15 bacterial associates (spanning 12 genera) cultivated from
spp. resulted in the identification of 440 putative and classifiable secondary metabolite biosynthetic gene clusters (BGCs), encompassing varied terpene-, polyketide-, bacteriocin-, and nonribosomal peptide-synthase BGCs. This points towards a widespread yet uncharted capacity of octocoral-associated bacteria to synthetize a broad range of natural products. However, to extend our knowledge and foster the near-future laboratory production of bioactive compounds from (cultivatable and currently uncultivatable) octocoral symbionts, optimal blending between targeted metagenomics, DNA recombinant technologies, improved symbiont cultivation, functional genomics, and analytical chemistry are required. Such a multidisciplinary undertaking is key to achieving a sustainable response to the urgent industrial demand for novel drugs and enzyme varieties.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>30518125</pmid><doi>10.3390/md16120485</doi><orcidid>https://orcid.org/0000-0002-4763-0662</orcidid><orcidid>https://orcid.org/0000-0003-3702-9192</orcidid><orcidid>https://orcid.org/0000-0002-5932-4101</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1660-3397 |
| ispartof | Marine drugs, 2018-12, Vol.16 (12), p.485 |
| issn | 1660-3397 1660-3397 |
| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_81f7354cf171407fbf14e4d0f1c3d7e0 |
| source | Publicly Available Content (ProQuest); PubMed Central |
| subjects | Analytical chemistry Antibiotics Anticancer properties Antifouling substances Antiviral agents Bacteria Bacteriocins Bioactive compounds Biological activity biopharmaceuticals bioprospection Biosynthesis Biotechnology blue economy Clinical trials Consortia Coral reefs Deoxyribonucleic acid DNA Fungi Fungicides Gene clusters Genera Genomes gorgonians host–microbe interactions Inflammation Invertebrates Marine invertebrates Medicine Metabolites Metagenomics Microorganisms Natural products Polyketides Recombinants Review Secondary metabolites Steroid hormones Symbionts Terpenes |
| title | Bioactive Secondary Metabolites from Octocoral-Associated Microbes-New Chances for Blue Growth |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T22%3A01%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Bioactive%20Secondary%20Metabolites%20from%20Octocoral-Associated%20Microbes-New%20Chances%20for%20Blue%20Growth&rft.jtitle=Marine%20drugs&rft.au=Raimundo,%20In%C3%AAs&rft.date=2018-12-04&rft.volume=16&rft.issue=12&rft.spage=485&rft.pages=485-&rft.issn=1660-3397&rft.eissn=1660-3397&rft_id=info:doi/10.3390/md16120485&rft_dat=%3Cproquest_doaj_%3E2179225648%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4535-196a84d539e79816b181e8fc639ae41b6455941b540072a0e05699fefb9185043%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2582831328&rft_id=info:pmid/30518125&rfr_iscdi=true |