Injectable bioactive glass/sodium alginate hydrogel with immunomodulatory and angiogenic properties for enhanced tendon healing

Tendon healing is a complex process involving inflammation, proliferation, and remodeling, eventually achieving a state of hypocellularity and hypovascularity. Currently, few treatments can satisfactorily restore the structure and function of native tendon. Bioactive glass (BG) has been shown to pos...

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Bibliographic Details
Published in:Bioengineering & translational medicine 2023-01, Vol.8 (1), p.e10345-n/a
Main Authors: Xu, Hongtao, Zhu, Yanlun, Xu, Jiankun, Tong, Wenxue, Hu, Shiwen, Chen, Yi‐Fan, Deng, Shuai, Yao, Hao, Li, Jie, Lee, Chien‐Wei, Chan, Hon Fai
Format: Article
Language:English
Subjects:
Angiogenesis
Antibodies
Antigens
bioactive glass
Bioglass
Biological activity
Biomechanics
Biomedical materials
Collagen
Healing
hydrogel
Hydrogels
immunomodulatory
injectable
Macrophages
Mechanical properties
Modulus of elasticity
Range of motion
Skin
Sodium alginate
Surgery
tendon healing
Tendons
Tissue engineering
Ultimate loads
Wound healing
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Summary:Tendon healing is a complex process involving inflammation, proliferation, and remodeling, eventually achieving a state of hypocellularity and hypovascularity. Currently, few treatments can satisfactorily restore the structure and function of native tendon. Bioactive glass (BG) has been shown to possess immunomodulatory and angiogenic properties. In this study, we investigated whether an injectable hydrogel fabricated of BG and sodium alginate (SA) could be applied to enhance tenogenesis following suture repair of injured tendon. We demonstrated that BG/SA hydrogel significantly accelerated tenogenesis without inducing heterotopic ossification based on histological analysis. The therapeutic effect could attribute to increased angiogenesis and M1 to M2 phenotypic switch of macrophages within 7 days post‐surgery. Morphological characterization demonstrated that BG/SA hydrogel partially reverted the pathological changes of Achilles tendon, including increased length and cross‐sectional area (CSA). Finally, biomechanical test showed that BG/SA hydrogel significantly improved ultimate load, failure stress, and tensile modulus of the repaired tendon. In conclusion, administration of an injectable BG/SA hydrogel can be a novel and promising therapeutic approach to augment Achilles tendon healing in conjunction with surgical intervention.
ISSN:2380-6761
2380-6761
DOI:10.1002/btm2.10345