Retinal stem cells modulate proliferative parameters to coordinate post-embryonic morphogenesis in the eye of fish

Combining clonal analysis with a computational agent based model, we investigate how tissue-specific stem cells for neural retina (NR) and retinal pigmented epithelium (RPE) of the teleost medaka ( ) coordinate their growth rates. NR cell division timing is less variable, consistent with an upstream...

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Published in:eLife 2019-03, Vol.8
Main Authors: Tsingos, Erika, Höckendorf, Burkhard, Sütterlin, Thomas, Kirchmaier, Stephan, Grabe, Niels, Centanin, Lazaro, Wittbrodt, Joachim
Format: Article
Language:English
Subjects:
agent based model
Animals
Cell division
Cell proliferation
ciliary marginal zone
clonal analysis
Cloning
Computational and Systems Biology
Computer applications
Developmental Biology
Embryos
Epithelium
Growth rate
Medaka (Oryzias latipes)
Morphogenesis
Oryzias
Progenitor cells
Retina
Retina - growth & development
Retinal pigment epithelium
stem cell dynamics
Stem cells
Stem Cells - physiology
Transplants & implants
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cited_by cdi_FETCH-LOGICAL-c475t-65ffd40e1ae89ad1beb81fc343dbc5bd52a272ae4b254e0cd8bb3210efd88a7e3
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creator Tsingos, Erika
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Wittbrodt, Joachim
description Combining clonal analysis with a computational agent based model, we investigate how tissue-specific stem cells for neural retina (NR) and retinal pigmented epithelium (RPE) of the teleost medaka ( ) coordinate their growth rates. NR cell division timing is less variable, consistent with an upstream role as growth inducer. RPE cells divide with greater variability, consistent with a downstream role responding to inductive signals. Strikingly, the arrangement of the retinal ciliary marginal zone niche results in a spatially biased random lineage loss, where stem- and progenitor cell domains emerge spontaneously. Further, our data indicate that NR cells orient division axes to regulate organ shape and retinal topology. We highlight an unappreciated mechanism for growth coordination, where one tissue integrates cues to synchronize growth of nearby tissues. This strategy may enable evolution to modulate cell proliferation parameters in one tissue to adapt whole-organ morphogenesis in a complex vertebrate organ.
doi_str_mv 10.7554/eLife.42646
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source Publicly Available Content Database; PubMed
subjects agent based model
Animals
Cell division
Cell proliferation
ciliary marginal zone
clonal analysis
Cloning
Computational and Systems Biology
Computer applications
Developmental Biology
Embryos
Epithelium
Growth rate
Medaka (Oryzias latipes)
Morphogenesis
Oryzias
Progenitor cells
Retina
Retina - growth & development
Retinal pigment epithelium
stem cell dynamics
Stem cells
Stem Cells - physiology
Transplants & implants
title Retinal stem cells modulate proliferative parameters to coordinate post-embryonic morphogenesis in the eye of fish
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