Microdiscectomy compared with transforaminal epidural steroid injection for persistent radicular pain caused by prolapsed intervertebral disc: the NERVES RCT

Sciatica is a common condition reported to affect > 3% of the UK population at any time and is most often caused by a prolapsed intervertebral disc. Currently, there is no uniformly adopted treatment strategy. Invasive treatments, such as surgery (i.e. microdiscectomy) and transforaminal epidural...

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Published in:Health technology assessment (Winchester, England) England), 2021-04, Vol.25 (24), p.1-86
Main Authors: Wilby, Martin J, Best, Ashley, Wood, Eifiona, Burnside, Girvan, Bedson, Emma, Short, Hannah, Wheatley, Dianne, Hill-McManus, Daniel, Sharma, Manohar, Clark, Simon, Bostock, Jennifer, Hay, Sally, Baranidharan, Ganesan, Price, Cathy, Mannion, Richard, Hutchinson, Peter J, Hughes, Dyfrig A, Marson, Anthony, Williamson, Paula R
Format: Article
Language:English
Subjects:
clinical trial
cost-effectiveness analysis
health technology assessment
injection
microdiscectomy
prolapsed disc
prolapsed intervertebral disc
randomised
sciatica
surgery
transforaminal epidural steroid injection
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Summary:Sciatica is a common condition reported to affect > 3% of the UK population at any time and is most often caused by a prolapsed intervertebral disc. Currently, there is no uniformly adopted treatment strategy. Invasive treatments, such as surgery (i.e. microdiscectomy) and transforaminal epidural steroid injection, are often reserved for failed conservative treatment. To compare the clinical effectiveness and cost-effectiveness of microdiscectomy with transforaminal epidural steroid injection for the management of radicular pain secondary to lumbar prolapsed intervertebral disc for non-emergency presentation of sciatica of
ISSN:1366-5278
2046-4924
DOI:10.3310/HTA25240