Bone and Extracellular Signal-Related Kinase 5 (ERK5)

Bones are vital for anchoring muscles, tendons, and ligaments, serving as a fundamental element of the human skeletal structure. However, our understanding of bone development mechanisms and the maintenance of bone homeostasis is still limited. Extracellular signal-related kinase 5 (ERK5), a recentl...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2024-05, Vol.14 (5), p.556
Main Authors: Wen, Lei, Liu, Zirui, Zhou, Libo, Liu, Zhongcheng, Li, Qingda, Geng, Bin, Xia, Yayi
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Blood vessels
bone
Bone and Bones - enzymology
Bone and Bones - metabolism
Bone marrow
Bone turnover
cancer
Cartilage
Endothelium
Enzymes
ERK5
Extracellular signal-regulated kinase
Growth factors
Heart attacks
Homeostasis
Humans
Kinases
MAP kinase
Mitogen-Activated Protein Kinase 7 - metabolism
Muscles
Osteoporosis
Phosphorylation
Physiology
Proteins
Tendons
Transcription factors
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Summary:Bones are vital for anchoring muscles, tendons, and ligaments, serving as a fundamental element of the human skeletal structure. However, our understanding of bone development mechanisms and the maintenance of bone homeostasis is still limited. Extracellular signal-related kinase 5 (ERK5), a recently identified member of the mitogen-activated protein kinase (MAPK) family, plays a critical role in the pathogenesis and progression of various diseases, especially neoplasms. Recent studies have highlighted ERK5's significant role in both bone development and bone-associated pathologies. This review offers a detailed examination of the latest research on ERK5 in different tissues and diseases, with a particular focus on its implications for bone health. It also examines therapeutic strategies and future research avenues targeting ERK5.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom14050556