Review on plant antimicrobials: a mechanistic viewpoint

Microbial resistance to classical antibiotics and its rapid progression have raised serious concern in the treatment of infectious diseases. Recently, many studies have been directed towards finding promising solutions to overcome these problems. Phytochemicals have exerted potential antibacterial a...

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Bibliographic Details
Published in:Antimicrobial resistance & infection control 2019-07, Vol.8 (1), p.118-118, Article 118
Main Authors: Khameneh, Bahman, Iranshahy, Milad, Soheili, Vahid, Fazly Bazzaz, Bibi Sedigheh
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotic resistance
Antibiotic-resistant
Antibiotics
Antimicrobial activity
Antimicrobial agents
Bacteria
Bacterial infections
Bacterial proteins
Bioactive compounds
Biosynthesis
Care and treatment
Cell division
Combination therapy
Communicable diseases
Deoxyribonucleic acid
Disease control
DNA
Drug resistance
Drugs
E coli
Enzymes
Infections
Infectious diseases
Mechanism of action
Medical research
Microbial drug resistance
Natural products
Pathogenic microorganisms
Peptides
Phytochemicals
Review
Synergistic effect
Tetracyclines
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Summary:Microbial resistance to classical antibiotics and its rapid progression have raised serious concern in the treatment of infectious diseases. Recently, many studies have been directed towards finding promising solutions to overcome these problems. Phytochemicals have exerted potential antibacterial activities against sensitive and resistant pathogens via different mechanisms of action. In this review, we have summarized the main antibiotic resistance mechanisms of bacteria and also discussed how phytochemicals belonging to different chemical classes could reverse the antibiotic resistance. Next to containing direct antimicrobial activities, some of them have exerted in vitro synergistic effects when being combined with conventional antibiotics. Considering these facts, it could be stated that phytochemicals represent a valuable source of bioactive compounds with potent antimicrobial activities.
ISSN:2047-2994
2047-2994
DOI:10.1186/s13756-019-0559-6