Serum Concentration of Plant Sterol Oxidation Products (POP) Compared to Cholesterol Oxidation Products (COP) after Intake of Oxidized Plant Sterols: A Randomised, Placebo-Controlled, Double-Blind Dose‒Response Pilot Study

Plant sterols (PS) are oxidized to PS oxidation products (POP). This study quantified the change in serum POP compared to cholesterol oxidation products (COP) after the intake of increasing POP doses. This was a double-blind, randomized, placebo-controlled, dose‒response pilot study with healthy ind...

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Bibliographic Details
Published in:Nutrients 2019-09, Vol.11 (10), p.2319
Main Authors: Lin, Yuguang, Koppenol, Wieneke P, Knol, Diny, Vermeer, Mario A, Hiemstra, Harry, Friedrichs, Silvia, Lütjohann, Dieter, Trautwein, Elke A
Format: Article
Language:English
Subjects:
Adult
Aged
Atherosclerosis
autoxidation
Cholesterol
Cholesterol - blood
cholesterol oxidation products (cop)
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Cookies
Cooking
Cytotoxicity
Dietary intake
Double-Blind Method
Double-blind studies
Female
Food
Functional Food
Germany
High density lipoprotein
Humans
Lipid Metabolism
Lipids
Low density lipoprotein
Male
Margarine
Middle Aged
nutrition study
Oxidation
Oxidation-Reduction
oxysterols
phytosterols
Phytosterols - administration & dosage
Phytosterols - blood
Pilot Projects
plant sterol oxidation products (pop)
plant sterols
Plasma
Serum lipids
Sterols
Studies
Time Factors
Triglycerides
Triglycerides - blood
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Summary:Plant sterols (PS) are oxidized to PS oxidation products (POP). This study quantified the change in serum POP compared to cholesterol oxidation products (COP) after the intake of increasing POP doses. This was a double-blind, randomized, placebo-controlled, dose‒response pilot study with healthy individuals in four groups (15 per group). The control group received products with no added PS or POP and treatment groups received daily 20-25 g margarine with added PS (mean 3 g/d) and two cookies (~28 g) for six weeks. Cookies delivered 8.7 (low-dose), 15.2 (medium-dose), or 37.2 (high-dose) mg/d POP. Fasting serum POP and COP were measured at the baseline, days 14, 28, and 42 in all participants and days 7, 21, and 35 in a subset. Sixty individuals completed the study; 52 were included in per protocol analysis. Serum POP increased with increasing POP intake and plateaued at dose >15 mg/d. Stabilized POP concentrations were (mean ± SD) 38.9 ± 6.9, 91.0 ± 27.9, 144.4 ± 37.9 and 203.0 ± 63.7 nmol/L, for control, low-, medium-, and high-dose POP groups, respectively. For all groups, the serum COP ranged from 213 to 262 nmol/L and the average POP/COP ratio was
ISSN:2072-6643
2072-6643
DOI:10.3390/nu11102319