The dopamine agonist bromocriptine differentially affects fronto-striatal functional connectivity during working memory

We investigated the effect of bromocriptine, a dopamine agonist, on individual differences in behavior as well as frontal-striatal connectivity during a working memory task. After dopaminergic augmentation, frontal-striatal connectivity in low working memory capacity individuals increases, correspon...

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Bibliographic Details
Published in:Frontiers in human neuroscience 2011, Vol.5, p.32-32
Main Authors: Wallace, Deanna L, Vytlacil, Jason J, Nomura, Emi M, Gibbs, Sasha E B, D'Esposito, Mark
Format: Article
Language:English
Subjects:
Agonists
Bromocriptine
Dopamine
Dopamine receptors
fMRI
functional connectivity
Memory
Mental task performance
Neostriatum
Neuroscience
Short term memory
Studies
working memory
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Summary:We investigated the effect of bromocriptine, a dopamine agonist, on individual differences in behavior as well as frontal-striatal connectivity during a working memory task. After dopaminergic augmentation, frontal-striatal connectivity in low working memory capacity individuals increases, corresponding with behavioral improvement whereas decreases in connectivity in high working memory capacity individuals are associated with poorer behavioral performance. These findings corroborate an inverted U-shape response of dopamine function in behavioral performance and provide insight on the corresponding neural mechanisms.
ISSN:1662-5161
1662-5161
DOI:10.3389/fnhum.2011.00032