Maternal early mid-pregnancy adiponectin in relation to infant birth weight and the likelihood of being born large-for-gestational-age

This study aimed to evaluate the association of maternal adiponectin with infant birth size in 1349 pregnant women at Uppsala University Hospital, Sweden. The mean age of the women was 31.0 years, and 40.9% were nulliparous. Maternal early mid-pregnancy adiponectin was measured in microgram/mL. Line...

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Bibliographic Details
Published in:Scientific reports 2023-11, Vol.13 (1), p.20919-20919, Article 20919
Main Authors: Lindberger, Emelie, Larsson, Anders, Kunovac Kallak, Theodora, Sundström Poromaa, Inger, Wikström, Anna-Karin, Österroos, Anna, Ahlsson, Fredrik
Format: Article
Language:English
Subjects:
692/308/53
692/699/1702/393
692/700/1720/3194
Adiponectin
Adult
Age
Birth Weight
Diabetes Mellitus
Female
Humanities and Social Sciences
Humans
Infant
Infant, Large for Gestational Age
Infants
Male
multidisciplinary
Parity
Pregnancy
Regression analysis
Science
Science (multidisciplinary)
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Summary:This study aimed to evaluate the association of maternal adiponectin with infant birth size in 1349 pregnant women at Uppsala University Hospital, Sweden. The mean age of the women was 31.0 years, and 40.9% were nulliparous. Maternal early mid-pregnancy adiponectin was measured in microgram/mL. Linear regression models were performed to evaluate the association between adiponectin and infant birth weight. Logistic regression models were used to evaluate adiponectin in relation to the odds of giving birth to an infant large-for-gestational-age (LGA, infant birth weight standard deviation score > 90th percentile). Adjustments were made for early pregnancy BMI and diabetes mellitus. Prior adjustments, adiponectin was inversely associated with infant birth weight (β − 17.1, 95% confidence interval (CI) − 26.8 to − 7.4 g, P  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-48027-2