Identification of a Hippocampus‐to‐Zona Incerta Projection involved in Motor Learning

Motor learning (ML), which plays a fundamental role in growth and physical rehabilitation, involves different stages of learning and memory processes through different brain regions. However, the neural mechanisms that underlie ML are not sufficiently understood. Here, a previously unreported neuron...

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Bibliographic Details
Published in:Advanced science 2024-09, Vol.11 (33), p.e2307185-n/a
Main Authors: Zhang, Zhuo‐Hang, Wang, Bo, Peng, Yan, Xu, Ya‐Wei, Li, Chang‐Hong, Ning, Ya‐Lei, Zhao, Yan, Shan, Fa‐Bo, Zhang, Bo, Yang, Nan, Zhang, Jing, Chen, Xing, Xiong, Ren‐Ping, Zhou, Yuan‐Guo, Li, Ping
Format: Article
Language:English
Subjects:
acquisition
Animals
Behavior
Brain research
consolidation
hippocampus
Hippocampus - physiology
Kinases
Labeling
Learning - physiology
Male
Memory
Mice
Models, Animal
motor learning
Neural Pathways - physiology
Optogenetics - methods
Parkinson's disease
projections
retention/retrieval
zona incerta
Zona Incerta - physiology
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Summary:Motor learning (ML), which plays a fundamental role in growth and physical rehabilitation, involves different stages of learning and memory processes through different brain regions. However, the neural mechanisms that underlie ML are not sufficiently understood. Here, a previously unreported neuronal projection from the dorsal hippocampus (dHPC) to the zona incerta (ZI) involved in the regulation of ML behaviors is identified. Using recombinant adeno‐associated virus, the projections to the ZI are surprisingly identified as originating from the dorsal dentate gyrus (DG) and CA1 subregions of the dHPC. Furthermore, projection‐specific chemogenetic and optogenetic manipulation reveals that the projections from the dorsal CA1 to the ZI play key roles in the acquisition and consolidation of ML behaviors, whereas the projections from the dorsal DG to the ZI mediate the retrieval/retention of ML behaviors. The results reveal new projections from the dorsal DG and dorsal CA1 to the ZI involved in the regulation of ML and provide insight into the stages over which this regulation occurs. The results reveal a previously unreported neuronal projection from dHPC to ZI involved in the regulation of ML behavior. The projections from the dorsal CA1 to the ZI play key roles in the acquisition and consolidation of ML behavior, whereas projections from the dorsal DG to the ZI mediate the retrieval/retention of ML behavior.
ISSN:2198-3844
2198-3844
DOI:10.1002/advs.202307185