Effect of maternal diabetes on gliogensis in neonatal rat hippocampus

Background: Diabetes in pregnancy is a common metabolic disorder associated with various adverse outcomes in the offspring including impairments in attention and memory and alterations in social behavior. Glial cells are proven to have a critical role in normal function of neurons, and alteration in...

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Published in:Advanced biomedical research 2016-01, Vol.5 (1), p.142-142
Main Authors: Sadeghi, Akram, Esfandiary, Ebrahim, Hami, Javad, Khanahmad, Hossein, Hejazi, Zahra, Razavi, Shahnaz
Format: Article
Language:English
Subjects:
Animal cognition
Brain
Diabetes
Glial cell
hippocampus
Hyperglycemia
Insulin
maternal diabetes
Medical research
Mothers
neonatal rat
Neurogenesis
Neurons
Original
Pregnancy
Researchers
Rodents
Studies
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container_title Advanced biomedical research
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Esfandiary, Ebrahim
Hami, Javad
Khanahmad, Hossein
Hejazi, Zahra
Razavi, Shahnaz
description Background: Diabetes in pregnancy is a common metabolic disorder associated with various adverse outcomes in the offspring including impairments in attention and memory and alterations in social behavior. Glial cells are proven to have a critical role in normal function of neurons, and alteration in their activity could contribute to disturbance in the brain function. The aim of this study was to investigate the effect of maternal diabetes on hippocampal mRNA expression and distribution pattern of glial fibrillary acidic protein (GFAP) immunoreactive glial cells in the dentate gyrus (DG) of rat neonate at postnatal day 14 (P14). Materials and Methods: Wistar female rats were randomly allocated in control, diabetic, and insulin-treated diabetic groups. Diabetes was induced by injection of streptozotocin from 4 weeks before gestation until parturition. After delivery, the male offspring was euthanized at P14. Results: Our results showed a significant higher level of hippocampal GFAP expression and an increase in the mean number of GFAP positive cells in the DG of diabetic group offspring (P < 0.05). We also found an insignificant up-regulation in the expression of GFAP and the mean number of positive cells in the insulin-treated diabetic group neonates as compared to control group (P > 0.05). Conclusion: The present study revealed that diabetes during pregnancy strongly increased the glial cells production in the developing rat hippocampus.
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Glial cells are proven to have a critical role in normal function of neurons, and alteration in their activity could contribute to disturbance in the brain function. The aim of this study was to investigate the effect of maternal diabetes on hippocampal mRNA expression and distribution pattern of glial fibrillary acidic protein (GFAP) immunoreactive glial cells in the dentate gyrus (DG) of rat neonate at postnatal day 14 (P14). Materials and Methods: Wistar female rats were randomly allocated in control, diabetic, and insulin-treated diabetic groups. Diabetes was induced by injection of streptozotocin from 4 weeks before gestation until parturition. After delivery, the male offspring was euthanized at P14. Results: Our results showed a significant higher level of hippocampal GFAP expression and an increase in the mean number of GFAP positive cells in the DG of diabetic group offspring (P &lt; 0.05). We also found an insignificant up-regulation in the expression of GFAP and the mean number of positive cells in the insulin-treated diabetic group neonates as compared to control group (P &gt; 0.05). Conclusion: The present study revealed that diabetes during pregnancy strongly increased the glial cells production in the developing rat hippocampus.</description><identifier>ISSN: 2277-9175</identifier><identifier>EISSN: 2277-9175</identifier><identifier>DOI: 10.4103/2277-9175.187376</identifier><identifier>PMID: 27656611</identifier><language>eng</language><publisher>India: Wolters Kluwer - Medknow Publications</publisher><subject>Animal cognition ; Brain ; Diabetes ; Glial cell ; hippocampus ; Hyperglycemia ; Insulin ; maternal diabetes ; Medical research ; Mothers ; neonatal rat ; Neurogenesis ; Neurons ; Original ; Pregnancy ; Researchers ; Rodents ; Studies</subject><ispartof>Advanced biomedical research, 2016-01, Vol.5 (1), p.142-142</ispartof><rights>Copyright Medknow Publications &amp; Media Pvt Ltd 2016</rights><rights>Copyright: © 2016 Advanced Biomedical Research 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c357l-81b0d954d747c732863b518f8b97f15781b899aa1651453e830ecc9da432f9a13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025925/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1845220042?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25744,27915,27916,37003,37004,44581,53782,53784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27656611$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sadeghi, Akram</creatorcontrib><creatorcontrib>Esfandiary, Ebrahim</creatorcontrib><creatorcontrib>Hami, Javad</creatorcontrib><creatorcontrib>Khanahmad, Hossein</creatorcontrib><creatorcontrib>Hejazi, Zahra</creatorcontrib><creatorcontrib>Razavi, Shahnaz</creatorcontrib><title>Effect of maternal diabetes on gliogensis in neonatal rat hippocampus</title><title>Advanced biomedical research</title><addtitle>Adv Biomed Res</addtitle><description>Background: Diabetes in pregnancy is a common metabolic disorder associated with various adverse outcomes in the offspring including impairments in attention and memory and alterations in social behavior. Glial cells are proven to have a critical role in normal function of neurons, and alteration in their activity could contribute to disturbance in the brain function. The aim of this study was to investigate the effect of maternal diabetes on hippocampal mRNA expression and distribution pattern of glial fibrillary acidic protein (GFAP) immunoreactive glial cells in the dentate gyrus (DG) of rat neonate at postnatal day 14 (P14). Materials and Methods: Wistar female rats were randomly allocated in control, diabetic, and insulin-treated diabetic groups. Diabetes was induced by injection of streptozotocin from 4 weeks before gestation until parturition. After delivery, the male offspring was euthanized at P14. Results: Our results showed a significant higher level of hippocampal GFAP expression and an increase in the mean number of GFAP positive cells in the DG of diabetic group offspring (P &lt; 0.05). We also found an insignificant up-regulation in the expression of GFAP and the mean number of positive cells in the insulin-treated diabetic group neonates as compared to control group (P &gt; 0.05). 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subjects Animal cognition
Brain
Diabetes
Glial cell
hippocampus
Hyperglycemia
Insulin
maternal diabetes
Medical research
Mothers
neonatal rat
Neurogenesis
Neurons
Original
Pregnancy
Researchers
Rodents
Studies
title Effect of maternal diabetes on gliogensis in neonatal rat hippocampus
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