Choroideremia associated with choroidal neovascularization treated with intravitreal bevacizumab

To report a rare case of central vision loss in a patient with choroideremia. A retrospective, interventional case report. A 13-year-old male with history of choroideremia presented with subacute loss of central acuity in his left eye. Examination and diagnostic testing revealed subretinal fibrosis...

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Published in:Clinical ophthalmology (Auckland, N.Z.) N.Z.), 2014-09, Vol.8 (default), p.1675-1679
Main Authors: Palejwala, Neal V, Lauer, Andreas K, Weleber, Richard G
Format: Article
Language:English
Subjects:
Acuity
Anatomy
anti-VEGF therapy
Atrophy
Case Report
Case studies
chorioretinal degeneration
choroidal neovascular membrane
Choroideremia
Diagnosis
Diagnostic systems
Drug therapy
Edema
Eye examinations
Fibrosis
Growth factors
hereditary choroidal dystrophy
Immunotherapy
intravitreal bevacizumab injection
Males
Monoclonal antibodies
Ophthalmology
Patients
Photoreceptors
Retina
Therapy
Tomography
Vascular endothelial growth factor
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Lauer, Andreas K
Weleber, Richard G
description To report a rare case of central vision loss in a patient with choroideremia. A retrospective, interventional case report. A 13-year-old male with history of choroideremia presented with subacute loss of central acuity in his left eye. Examination and diagnostic testing revealed subretinal fibrosis secondary to a choroidal neovascular membrane (CNVM). A trial of anti-vascular endothelial growth factor (VEGF) therapy with the injection of intravitreal bevacizumab was attempted. Mild improvements in acuity and anatomy were noted. Choroideremia is a rare hereditary choroidal dystrophy that predominantly affects males in the first and second decades of life. Visual acuity is usually spared until later in life. CNVM is a rare manifestation of choroideremia with only a handful of case reports presented in the literature. This case is unique in that it is the first reported case that received treatment with intravitreal anti-VEGF therapy.
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A retrospective, interventional case report. A 13-year-old male with history of choroideremia presented with subacute loss of central acuity in his left eye. Examination and diagnostic testing revealed subretinal fibrosis secondary to a choroidal neovascular membrane (CNVM). A trial of anti-vascular endothelial growth factor (VEGF) therapy with the injection of intravitreal bevacizumab was attempted. Mild improvements in acuity and anatomy were noted. Choroideremia is a rare hereditary choroidal dystrophy that predominantly affects males in the first and second decades of life. Visual acuity is usually spared until later in life. CNVM is a rare manifestation of choroideremia with only a handful of case reports presented in the literature. 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source Publicly Available Content (ProQuest); Taylor & Francis Open Access Journals; PubMed Central
subjects Acuity
Anatomy
anti-VEGF therapy
Atrophy
Case Report
Case studies
chorioretinal degeneration
choroidal neovascular membrane
Choroideremia
Diagnosis
Diagnostic systems
Drug therapy
Edema
Eye examinations
Fibrosis
Growth factors
hereditary choroidal dystrophy
Immunotherapy
intravitreal bevacizumab injection
Males
Monoclonal antibodies
Ophthalmology
Patients
Photoreceptors
Retina
Therapy
Tomography
Vascular endothelial growth factor
title Choroideremia associated with choroidal neovascularization treated with intravitreal bevacizumab
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