Dysregulated Expression of Antimicrobial Peptides in Skin Lesions of Patients with Cutaneous T-cell Lymphoma

Mycosis fungoides and Sézary syndrome belong to the group of primary cutaneous T-cell lymphomas. Because of the inflammatory appearance of the skin lesions, we hypothesized that antimicrobial peptides might be dysregulated in these conditions, similar to in inflammatory skin conditions. Samples from...

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Bibliographic Details
Published in:Acta dermato-venereologica 2020-01, Vol.100 (1), p.adv00017-6
Main Authors: Wehkamp, Ulrike, Jost, Marion, Wehkamp, Kai, Harder, Jürgen
Format: Article
Language:English
Subjects:
Adult
Aged
antimicrobial peptides
defence
Female
Humans
Immunohistochemistry
Investigative Report
Lymphoma, T-Cell, Cutaneous - genetics
Lymphoma, T-Cell, Cutaneous - pathology
Male
Middle Aged
mycosis fungoides
Prospective Studies
Skin - pathology
Skin Neoplasms - genetics
Skin Neoplasms - pathology
t-cell lymphoma
tumour
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Summary:Mycosis fungoides and Sézary syndrome belong to the group of primary cutaneous T-cell lymphomas. Because of the inflammatory appearance of the skin lesions, we hypothesized that antimicrobial peptides might be dysregulated in these conditions, similar to in inflammatory skin conditions. Samples from 20 patients with cutaneous T-cell lymphoma were analysed using immunohistochemistry and enzyme-linked immunoassay (ELISA) of skin washing fluids of hBD-2, hBD-3, RNase 7 and psoriasin. Immunohistochemistry results were compared with previous analyses of healthy and psoriatic skin. ELISA and immunohistochemistry revealed a higher expression of psoriasin in lesional cutaneous T-cell lymphoma compared with non-lesional and healthy samples. Immunohistochemistry showed an increase in hBD-2 in lesional cutaneous T-cell lymphoma skin compared with healthy skin. The expression profile of antimicrobial peptides in cutaneous T-cell lymphoma appears to be dysregulated, indicating a potential role of antimicrobial peptides in cutaneous T-cell lymphoma. A larger prospective study and functional studies are needed to improve our understanding of the role of antimicrobial peptides in cutaneous T-cell lymphoma.
ISSN:0001-5555
1651-2057
DOI:10.2340/00015555-3372