Recognizing and stabilizing miR-21 by chiral ruthenium(II) complexes

MiR-21, a non-coding miRNA with 22 nucleotides, plays an important part in the proliferation, invasion, and metastasis of tumor cells. The present study demonstrates that isomers of chiral ruthenium(II) complexes with alkynes (Λ-1 and Δ-1) were synthesized by Songogashira coupling reaction by using...

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Bibliographic Details
Published in:BMC chemistry 2020-04, Vol.14 (1), p.26-26, Article 26
Main Authors: Feng, Yin, Shu, Jing, Yao, Liangzhong, Lan, Yutao, Ye, Lianbao, Mei, Wenjie, Ding, Ying
Format: Article
Language:English
Subjects:
Alkynes
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Chiral ruthenium(II) complexes
FRET
Inorganic Chemistry
Isomers
MiR-21
Nuclei (cytology)
Nucleotides
Research Article
RNA binding property
Ruthenium
Ruthenium compounds
Tumors
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Summary:MiR-21, a non-coding miRNA with 22 nucleotides, plays an important part in the proliferation, invasion, and metastasis of tumor cells. The present study demonstrates that isomers of chiral ruthenium(II) complexes with alkynes (Λ-1 and Δ-1) were synthesized by Songogashira coupling reaction by using microwave-assisted synthetic technology. The isomers can recognize and stabilize miR-21, with the Λ-isomer showing a stronger binding capacity than the Δ-isomer. Further studies showed that both isomers can be uptaken by MDA-MB-231 cells and enriched in the nucleus. Treatment with the Λ-/Δ-isomer downregulated the expression of miR-21. In a word, the development of chiral ruthenium(II) complexes act as potential inhibitors against tumor cells by recognizing, stabilizing, and regulating the expression of miR-21.
ISSN:2661-801X
2661-801X
DOI:10.1186/s13065-020-00672-8