Paraoxonase 1 Phenotype and Mass in South Asian versus Caucasian Renal Transplant Recipients

• Published in: Journal of Lipids 2012-01, Vol.2012 (2012), p.218-222
• Main Authors: Maguire, Graham F., Connelly, Philip W., Nash, Michelle M., Rapi, Lindita, Yan, Andrew T., Prasad, G. V. Ramesh
• Format: Article
• Language: English
• ISSN: 2090-3030; 2090-3049
• DOI: 10.1155/2012/608580

South Asian renal transplant recipients have a higher incidence of cardiovascular disease compared with Caucasian renal transplant recipients. We carried out a study to determine whether paraoxonase 1, a novel biomarker for cardiovascular risk, was decreased in South Asian compared with Caucasian renal transplant recipients. Subjects were matched two to one on the basis of age and sex for a total of 129 subjects. Paraoxonase 1 was measured by mass, arylesterase activity, and two-substrate phenotype assay. Comparisons were made by using a matched design. The frequency of PON1 QQ, QR and RR phenotype was 56%, 37%, and 7% for Caucasian subjects versus 35%, 44%, and 21% for South Asian subjects (χ2=7.72, P=0.02). PON1 mass and arylesterase activity were not significantly different between South Asian and Caucasian subjects. PON1 mass was significantly associated with PON1 phenotype (P=0.0001), HDL cholesterol (P=0.009), LDL cholesterol (P=0.02), and diabetes status (P