Predictive Value of Delayed Graft Function Definitions Following Donation After Circulatory Death Renal Transplantation in the United Kingdom

• Published in: Transplant research and risk management 2022-06, Vol.14, p.21-33
• Main Authors: Stirnadel-Farrant, Heide A, Mu, George, Cooper-Blenkinsopp, Selin, Schroyer, Rosemary O, Thorneloe, Kevin S, Harrison, Ewen M, Andrews, Susan M.S
• Format: Article
• Language: English
• Subjects: dcd; delayed graft function; dgf; donation after circulatory death; Donation of organs, tissues, etc; Gifts; Kidneys; scr; serum creatinine; Transplantation
• ISSN: 1179-1616; 1179-1616
• DOI: 10.2147/TRRM.S320221

Purpose: A variety of definitions for delayed graft function (DGF) have been proposed, but none has consistently been shown to be superior for predicting long-term graft outcomes for kidney donation after circulatory death (DCD) transplantation. In this study, real-world clinical outcome data following DCD transplantation were explored to determine the value of various DGF definitions for predicting graft survival. Patients and Methods: Data from 4 centers registered in the UK-based National Health Service Blood and Transplant registry (2010 to mid-2015) were used to assess 4 definitions of DGF in this retrospective chart review study. Results: Depending on the definition used, the frequency of DGF ranged from 119/362 (32.9%) when DGF was determined with available registry data and based on a requirement for dialysis within 7 days post-transplantation, to 224/315 (71.1%) when based on failure to achieve a 10% fall in serum creatinine (SCr) versus baseline per 24 hours averaged over the first 72 hours. Patients without clinical DGF as determined by a physician upon chart review, or when defined as