Cannabis and the Anxiety of Fragmentation-A Systems Approach for Finding an Anxiolytic Cannabis Chemotype

is a medicinal herb with a diverse range of chemotypes that can exert both anxiolytic and anxiogenic effects on humans. Medical cannabis patients receiving organically grown cannabis from a single source were surveyed about the effectiveness of cannabis for treating anxiety. Patients rated cannabis...

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Bibliographic Details
Published in:Frontiers in neuroscience 2018-10, Vol.12, p.730-730
Main Authors: Kamal, Brishna S, Kamal, Fatima, Lantela, Daniel E
Format: Article
Language:English
Subjects:
3-Carene
Anxiety
Cannabinoids
Cannabis
CBD
Chronic obstructive pulmonary disease
Drug dosages
Drug use
Genomes
Herbal medicine
High-performance liquid chromatography
Medical marijuana
Medicinal plants
Nerolidol
Neuroscience
Patients
Post traumatic stress disorder
Sabinene
Statistical analysis
synergy
Terpenes
terpenoids
Terpinene
Tetrahydrocannabinol
THC
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Summary:is a medicinal herb with a diverse range of chemotypes that can exert both anxiolytic and anxiogenic effects on humans. Medical cannabis patients receiving organically grown cannabis from a single source were surveyed about the effectiveness of cannabis for treating anxiety. Patients rated cannabis as highly effective overall for treating anxiety with an average score of 8.03 on a Likert scale of 0 to 10 (0 = not effective, 10 = extremely effective). Patients also identified which strains they found the most or least effective for relieving their symptoms of anxiety. To find correlations between anxiolytic activity and chemotype, the top four strains voted most and least effective were analyzed by HPLC-MS/MS to quantify cannabinoids and GC-MS to quantify terpenes. Tetrahydrocannabinol (THC) and trans-nerolidol have statistically significant correlations with increased anxiolytic activity. Guiaol, eucalyptol, γ-terpinene, α-phellandrene, 3-carene, and sabinene hydrate all have significant correlations with decreased anxiolytic activity. Further studies are needed to better elucidate the entourage effects that contribute to the anxiolytic properties of cannabis varieties.
ISSN:1662-4548
1662-453X
1662-453X
DOI:10.3389/fnins.2018.00730