Value of apparent diffusion coefficient (ADC) in evaluating response of carcinoma of the cervix treated with chemoradiotherapy

Objective: To determine whether the apparent diffusion coefficient (ADC) value obtained by diffusion-weighted magnetic resonance imaging (DW-MRI) can be used as a reliable detector of response of carcinoma of the cervix treated with chemoradiotherapy, compared with conventional T2-weighted MRI.Desig...

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Bibliographic Details
Published in:SA journal of radiology 2013-03, Vol.17 (1), p.11-15
Main Authors: Le Roux, A.J., Gebremariam, F.A., Harmse, W.S
Format: Article
Language:English
Subjects:
Biomarkers
Biopsy
Brain cancer
Cancer therapies
Care and treatment
Case studies
Cervical cancer
Cervical carcinoma
Chemoradiotherapy
Diagnosis
Diffusion coefficient
Functional magnetic resonance imaging
Gynecology
Health aspects
Health sciences
Image processing
Magnetic resonance imaging
Morphology
NMR
Nuclear magnetic resonance
Patient outcomes
Patients
Pelvis
Radiotherapy
Risk factors
Statistical analysis
Tumors
Womens health
Work stations
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Summary:Objective: To determine whether the apparent diffusion coefficient (ADC) value obtained by diffusion-weighted magnetic resonance imaging (DW-MRI) can be used as a reliable detector of response of carcinoma of the cervix treated with chemoradiotherapy, compared with conventional T2-weighted MRI.Design: A prospective cohort study was performed.Setting: Department of Oncology, Universitas-National Hospital Complex, Bloemfontein.Subjects: Seventeen women with advanced cervical cancer, FIGO staging IIB - IVB, were selected for chemoradiation.Outcome measures: Patients underwent pelvic MRI before therapy, 14 days after onset of therapy, and in the last week of treatment (5th/6th week). Axial and sagittal conventional T2 was followed by DW-MRI in the axial plane from which a tumour region of interest (ROI) was manually drawn to calculate ADC values using b-values of 500 and 1 000 s/mm2.Results: ADC values for cervical carcinoma increased after treatment with chemoradiation. The most significant observation was seen 14 days after treatment was started. The mean ADC value increased with 20% (b=500 s/mm2) and 24% (b=1 000 s/mm2) (statistically significant, p
ISSN:1027-202X
2078-6778
DOI:10.4102/sajr.v17i1.203