Comparison of imported Plasmodium ovale curtisi and P. ovale wallikeri infections among patients in Spain, 2005-2011

Sequencing data from Plasmodium ovale genotypes co-circulating in multiple countries support the hypothesis that P. ovale curtisi and P. ovale wallikeri are 2 separate species. We conducted a multicenter, retrospective, comparative study in Spain of 21 patients who had imported P. ovale curtisi infe...

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Bibliographic Details
Published in:Emerging infectious diseases 2014-03, Vol.20 (3), p.409-416
Main Authors: Rojo-Marcos, Gerardo, Rubio-Muñoz, José Miguel, Ramírez-Olivencia, Germán, García-Bujalance, Silvia, Elcuaz-Romano, Rosa, Díaz-Menéndez, Marta, Calderón, María, García-Bermejo, Isabel, Ruiz-Giardín, José Manuel, Merino-Fernández, Francisco Jesús, Torrús-Tendero, Diego, Delgado-Iribarren, Alberto, Ribell-Bachs, Mónica, Arévalo-Serrano, Juan, Cuadros-González, Juan
Format: Article
Language:English
Subjects:
Adolescent
Adult
Causes of
Child
clinical features
Comorbidity
Diagnosis
epidemiology
Female
Genetic aspects
Health aspects
History, 21st Century
Humans
imported malaria
Malaria
Malaria - complications
Malaria - diagnosis
Malaria - epidemiology
Malaria - history
Malaria - parasitology
Male
Middle Aged
Physiological aspects
Plasmodium
Plasmodium ovale - classification
Plasmodium ovale - genetics
Plasmodium ovale curtisi
Plasmodium ovale wallikeri
Retrospective Studies
Spain
Spain - epidemiology
Thrombocytopenia - diagnosis
Thrombocytopenia - etiology
Young Adult
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Summary:Sequencing data from Plasmodium ovale genotypes co-circulating in multiple countries support the hypothesis that P. ovale curtisi and P. ovale wallikeri are 2 separate species. We conducted a multicenter, retrospective, comparative study in Spain of 21 patients who had imported P. ovale curtisi infections and 14 who had imported P. ovale wallikeri infections confirmed by PCR and gene sequencing during June 2005-December 2011. The only significant finding was more severe thrombocytopenia among patients with P. ovale wallikeri infection than among those with P. ovale curtisi infection (p = 0.031). However, we also found nonsignificant trends showing that patients with P. ovale wallikeri infection had shorter time from arrival in Spain to onset of symptoms, lower level of albumin, higher median maximum core temperature, and more markers of hemolysis than did those with P. ovale curtisi infection. Larger, prospective studies are needed to confirm these findings.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2003.130745