Following hearts, one cell at a time: recent applications of single-cell RNA sequencing to the understanding of heart disease

The mammalian heart contains heterogeneous cell types contributing to pathological changes in cardiac disease. In this Comment, we explore how single-cell transcriptomic approaches are unveiling intricate cellular mechanisms and gene co-expression networks that regulate the workings, and failings, o...

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Bibliographic Details
Published in:Nature communications 2018-10, Vol.9 (1), p.4434-4, Article 4434
Main Authors: Ackers-Johnson, Matthew, Tan, Wilson Lek Wen, Foo, Roger Sik-Yin
Format: Article
Language:English
Subjects:
631/337/2019
692/699/75
Aging
Animals
Biology
Cardiomyocytes
Cardiovascular disease
Cellular communication
Comment
Coronary artery disease
Fibroblasts
Gene expression
Gene sequencing
Heart
Heart diseases
Heart Diseases - genetics
Humanities and Social Sciences
Humans
Identification
multidisciplinary
Myocardium - pathology
Quality control
Ribonucleic acid
RNA
Science
Science (multidisciplinary)
Sequence Analysis, RNA
Single-Cell Analysis - methods
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Summary:The mammalian heart contains heterogeneous cell types contributing to pathological changes in cardiac disease. In this Comment, we explore how single-cell transcriptomic approaches are unveiling intricate cellular mechanisms and gene co-expression networks that regulate the workings, and failings, of the heart.
ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-018-06894-8