Lipid Peroxidation, Antioxidative Defense and Level of 8-Hydroxy-2-Deoxyguanosine in Cervical Cancer Patients

Oxidative stress has been associated with cervical cancer. Our aim was to examine lipid peroxidation and the extent of oxidative stress in women diagnosed with different stages of cervical cancer in order to evaluate its potential role in the evolution of cancer. We measured the concentration of thi...

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Bibliographic Details
Published in:Journal of medical biochemistry 2018-07, Vol.37 (3), p.336-345
Main Authors: Jelić, Marija, Mandić, Aljoša, Kladar, Nebojša, Sudji, Jan, Božin, Biljana, Srdjenović, Branislava
Format: Article
Language:English
Subjects:
8-Hydroxydeoxyguanosine
8-OHdG
Antioxidants
Cancer
Catalase
Cervical cancer
Cervix
Deoxyguanosine
Enzymatic activity
Gas chromatography
Glutathione
Glutathione peroxidase
Glutathione reductase
Glutathione transferase
glutathione-S-transferase
Lipid peroxidation
Lipids
Mass spectrometry
Mass spectroscopy
Original Paper
Oxidation
Oxidative stress
Pathogenesis
Peroxidase
Peroxidation
Spectrophotometry
super oxide dismutase
Superoxide dismutase
Thiobarbituric acid
Vitamin E
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Summary:Oxidative stress has been associated with cervical cancer. Our aim was to examine lipid peroxidation and the extent of oxidative stress in women diagnosed with different stages of cervical cancer in order to evaluate its potential role in the evolution of cancer. We measured the concentration of thiobarbituric acid reactive substances, activities of antioxidative enzymes and 8-hydroxy-2-deoxyguanosine in 153 subjects. Enzymatic activity as well as TBARS concentration were measured spectrophotometrically, while 8-OHdG was determined by gas chromatography-mass spectrometry. PPatients were categorized: group II H-SIL; group III FIGO Ia-Ib and group IV FIGO IIa-IV. Our results showed highly significant increase in the level of lipid peroxidation in group IV when com pared to the control group, group II and group III (p
ISSN:1452-8258
1452-8266
1452-8266
DOI:10.1515/jomb-2017-0053