Protective effect of crude sulphated polysaccharides from Sargassum Swartzii (Turn.) C.Ag. against acetaminophen induced liver toxicity in rats

Background Polysaccharides from seaweeds have been reported to possess biological activities with potential medicinal value. Present study was aimed to investigate hepatoprotective effect of crude sulphated polysaccharides extracted from Sargassum swartzii against acetaminophen-induced liver injury....

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Bibliographic Details
Published in:Clinical phytoscience 2019-02, Vol.5 (1), p.1-8, Article 14
Main Authors: Hira, Khan, Sultana, Viqar, Khatoon, Nasira, Ara, Jehan, Ehteshamul-Haque, Syed
Format: Article
Language:English
Subjects:
Acetaminophen
Alanine
Algae
Alkaline phosphatase
Analgesics
Bilirubin
Biochemistry
Body weight
Cholesterol
Creatinine
Diabetes
Enzymes
Gastroenterology
Glutathione
Gynecology
Hepatoprotective
Herbal medicine
Histology
Histopathology
L-Lactate dehydrogenase
Lactate dehydrogenase
Lactic acid
Lipid peroxidation
Lipids
Liver
Liver injury
Markers
Medicine
Medicine & Public Health
Original Contribution
Parameters
Pediatrics
Peroxidation
Pneumology/Respiratory System
Polysaccharides
Room temperature
Saccharides
Sargassum
Sargassum swartzii
Seaweeds
Silymarin
Sulphated polysaccharides
Toxicity
Toxicity testing
Toxicology
Triglycerides
Urea
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Summary:Background Polysaccharides from seaweeds have been reported to possess biological activities with potential medicinal value. Present study was aimed to investigate hepatoprotective effect of crude sulphated polysaccharides extracted from Sargassum swartzii against acetaminophen-induced liver injury. Methods The polysaccharides from S. swartzii was extracted at room temperature and at 70 °C and named as EW 1 and EW 2. These fraction was given orally to rats at 200 mg/kg body weight. Liver injury was induced by single intraperitoneal injection of acetaminophen. Hepatic marker enzymes; alanine aminotransferases (ALT), aspartate aminotransferases (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), bilirubin and other biochemical parameters; glucose, triglycerides, cholesterol, urea and creatinine were estimated in serum, while hepatic glutathione (GSH) and lipid peroxidation were measured in liver tissue. Histopathology of liver tissues was also carried out. Results Treatment with polysaccharides EW 1 & EW 2 fractions significantly ( p  
ISSN:2199-1197
2199-1197
DOI:10.1186/s40816-019-0108-0